Literature DB >> 10441004

Sublocalization of putative tumor suppressor gene loci on chromosome arm 14q in neuroblastoma.

M Theobald1, H Christiansen, A Schmidt, B Melekian, N Wolkewitz, N M Christiansen, C Brinkschmidt, F Berthold, F Lampert.   

Abstract

RFLP and microsatellite analysis with 23 polymorphic markers spanning the entire long arm of chromosome 14 in 108 neuroblastomas showed allelic loss in 19 out of 107 (18%) informative tumors, placing 14q among the most frequently affected chromosomal regions in neuroblastoma. One minimal deletion region could be sublocalized in 17 of 19 cases between markers D14S1 and D14S16, and a second one between markers D14S17 and D14S23 in band 14q32. Furthermore, breakpoints in bands 14q23 and 14q12 were detected. These results suggest the presence of at least two putative tumor suppressor gene loci on chromosome 14. Survival analyses revealed no prognostic impact of allelic loss of 14q in neuroblastoma. Genes Chromosomes Cancer 26:40-46, 1999. Copyright 1999 Wiley-Liss, Inc.

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Year:  1999        PMID： 10441004

Source DB:  PubMed          Journal:  Genes Chromosomes Cancer        ISSN： 1045-2257            Impact factor:   5.006


  6 in total

Review 1.  Neuroblastoma tumour genetics: clinical and biological aspects.

Authors:  N Bown
Journal:  J Clin Pathol       Date:  2001-12       Impact factor: 3.411

Review 2.  Current status of human chromosome 14.

Authors:  D Kamnasaran; D W Cox
Journal:  J Med Genet       Date:  2002-02       Impact factor: 6.318

3.  Loss of 14q chromosome in oligodendroglial and astrocytic tumors.

Authors:  Charles Dichamp; Sophie Taillibert; Lucinda Aguirre-Cruz; Julie Lejeune; Yannick Marie; Michèle Kujas; Jean-Yves Delattre; Khe Hoang-Xuan; Marc Sanson
Journal:  J Neurooncol       Date:  2004-05       Impact factor: 4.130

4.  Neuroblastomas with chromosome 11q loss and single copy MYCN comprise a biologically distinct group of tumours with adverse prognosis.

Authors:  M E Luttikhuis; J E Powell; S A Rees; T Genus; S Chughtai; P Ramani; J R Mann; C M McConville
Journal:  Br J Cancer       Date:  2001-08-17       Impact factor: 7.640

5.  Detailed deletion mapping of chromosome band 14q32 in human neuroblastoma defines a 1.1-Mb region of common allelic loss.

Authors:  M Hoshi; N Otagiri; H O Shiwaku; S Asakawa; N Shimizu; Y Kaneko; R Ohi; Y Hayashi; A Horii
Journal:  Br J Cancer       Date:  2000-06       Impact factor: 7.640

6.  KIT Mutation and Loss of 14q May Be Sufficient for the Development of Clinically Symptomatic Very Low-Risk GIST.

Authors:  Olaf Karl Klinke; Tuba Mizani; Gouri Baldwin; Brigitte Bancel; Mojgan Devouassoux-Shisheboran; Jean-Yves Scoazec; Pierre-Paul Bringuier; Regina Feederle; Anna Jauch; Katrin Hinderhofer; Philippe Taniere; Henri-Jacques Delecluse
Journal:  PLoS One       Date:  2015-06-23       Impact factor: 3.240
  6 in total

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