Literature DB >> 10440085

Dependence of mesolimbic dopamine transmission on delta9-tetrahydrocannabinol.

G Tanda1, P Loddo, G Di Chiara.   

Abstract

Rats were administered daily for 8 days with increasing doses (2-12 mg/kg/day) of delta9-tetrahydrocannabinol (delta9-THC) and than challenged with different doses of SR141716A, an antagonist of cannabinoid receptors. SR141716A dose dependently reduced dialysate dopamine (DA) in the nucleus accumbens shell and precipitated a physical withdrawal syndrome. No such effects were obtained after administration of SR141716A to saline controls.

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Year:  1999        PMID： 10440085     DOI： 10.1016/s0014-2999(99)00384-2

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


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