Literature DB >> 10439937

[The effect of bromantane on the behavior of inbred mouse strains with different phenotypes of emotional stress reaction].

S B Seredenin1, A G Miramedova, M M Kozlovskaia.   

Abstract

Per os administration of bromantan (2-[n-bromphenyl]-aminoadamantan) in doses of 40-50 mg/kg prevents the fixed posture reaction and reduces the level of defecation in Balb/c mice in the "open field" test and activates their behavior in the "elevated plus maze" test. It increases the motor activity of C57B1/c mice in both tests. It is concluded that an anxiolytic effect is present in the spectrum of pharmacological properties of bromantan.

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Year:  1999        PMID: 10439937

Source DB:  PubMed          Journal:  Eksp Klin Farmakol        ISSN: 0869-2092


  1 in total

1.  The effect of ladasten on gene expression in the rat brain.

Authors:  Yu V Vakhitova; R S Yamidanov; V A Vakhitov; S B Seredenin
Journal:  Dokl Biochem Biophys       Date:  2005 Mar-Apr       Impact factor: 0.788

  1 in total

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