| Literature DB >> 10439484 |
P M Abreu1, E S Martins, O Kayser, K U Bindseil, K Siems, A Seemann, J Frevert.
Abstract
Following an ethnobotanical search carried out in Guinea-Bissau, eighteen extracts derived from sixteen medicinal species were screened for antimicrobial, antitumor and antileishmania activity. Significant antitumor activity was found for Holarrhena floribunda against KB (squamous carcinoma), SK-Mel 28 (melanoma), A 549 (lung carcinoma) and MDA-MB 231 (mamma carcinoma) cell lines, with corresponding IC50 values of 7.9, 9.0, 3.4 and 9.9 micrograms/ml. Khaya senegalensis and Anthostema senegalense exhibited a significant activity against Leishmania donovani with IC50 values of 9.8 and 9.1 micrograms/ml, respectively. Most of the extracts showed week or moderate antibacterial and antifungal activity, with MIC values in the range 0.25-1.0 mg/ml. Active extracts were submitted to bioassay-guided fractionation, and the IC50 and MIC of the active fractions were determined.Entities:
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Year: 1999 PMID： 10439484 DOI： 10.1016/S0944-7113(99)80008-7
Source DB: PubMed Journal: Phytomedicine ISSN： 0944-7113 Impact factor: 5.340