Literature DB >> 10438902

Cutting edge: immature dendritic cells generated from monocytes in the presence of TGF-beta 1 express functional C-C chemokine receptor 6.

D Yang1, O M Howard, Q Chen, J J Oppenheim.   

Abstract

Although CD34+ progenitor-derived immature dendritic cells (DCs) express CCR6, several recent studies reported that monocyte-derived immature DCs do not do so. We observed that DCs generated from monocytes in the presence of GM-CSF, IL-4, and TGF-beta 1 consistently responded to liver and activation-regulated chemokine (LARC, also known as macrophage inflammatory protein-3 alpha). These immature DCs expressed one class of high-affinity binding sites for LARC, and expressed both CCR6 mRNA and protein. Therefore, LARC-CCR6 interaction presumably also contributes to the regulation of trafficking of monocyte-derived DCs, and utilization of TGF-beta can potentially provide a ready source of CCR6+ monocyte-derived DCs for therapeutic purposes.

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Year:  1999        PMID： 10438902

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  26 in total

Review 1.  Immune chemokines and their receptors: the key elements in the genesis, homeostasis and function of the immune system.

Authors:  O Yoshie
Journal:  Springer Semin Immunopathol       Date:  2000

2.  Impaired lung dendritic cell activation in CCR2 knockout mice.

Authors:  Bo-Chin Chiu; Christine M Freeman; Valerie R Stolberg; Jerry S Hu; Kyriaki Zeibecoglou; Bao Lu; Craig Gerard; Israel F Charo; Sergio A Lira; Stephen W Chensue
Journal:  Am J Pathol       Date:  2004-10       Impact factor: 4.307

3.  Effects of MIP-1 alpha, MIP-3 alpha, and MIP-3 beta on the induction of HIV Gag-specific immune response with DNA vaccines.

Authors:  Ruijiang Song; Shuqin Liu; Kam W Leong
Journal:  Mol Ther       Date:  2007-03-13       Impact factor: 11.454

4.  Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate.

Authors:  O M Zack Howard; Hui Fang Dong; Shao Bo Su; Rachel R Caspi; Xin Chen; Paul Plotz; Joost J Oppenheim
Journal:  Blood       Date:  2005-02-15       Impact factor: 22.113

Review 5.  Dendritic cell biology and regulation of dendritic cell trafficking by chemokines.

Authors:  C Caux; S Ait-Yahia; K Chemin; O de Bouteiller; M C Dieu-Nosjean; B Homey; C Massacrier; B Vanbervliet; A Zlotnik; A Vicari
Journal:  Springer Semin Immunopathol       Date:  2000

Review 6.  Converting nonhuman primate dendritic cells into potent antigen-specific cellular immunosuppressants by genetic modification.

Authors:  Asiedu Clement; Alexander Pereboev; David T Curiel; Sai Sai Dong; Anne Hutchings; Judith M Thomas
Journal:  Immunol Res       Date:  2002       Impact factor: 2.829

7.  The transmembrane form of the CX3CL1 chemokine fractalkine is expressed predominantly by epithelial cells in vivo.

Authors:  A D Lucas; N Chadwick; B F Warren; D P Jewell; S Gordon; F Powrie; D R Greaves
Journal:  Am J Pathol       Date:  2001-03       Impact factor: 4.307

Review 8.  CCR6 as a mediator of immunity in the lung and gut.

Authors:  Toshihiro Ito; William F Carson; Karen A Cavassani; Judith M Connett; Steven L Kunkel
Journal:  Exp Cell Res       Date:  2011-03-10       Impact factor: 3.905

9.  A human dendritic cell subset receptive to the Venezuelan equine encephalitis virus-derived replicon particle constitutively expresses IL-32.

Authors:  Kevin P Nishimoto; Amanda K Laust; Edward L Nelson
Journal:  J Immunol       Date:  2008-09-15       Impact factor: 5.422

10.  Up-regulation of CC chemokine receptor 6 on tonsillar T cells and its induction by in vitro stimulation with alpha-streptococci in patients with pustulosis palmaris et plantaris.

Authors:  T Yoshizaki; N Bandoh; S Ueda; H Nozawa; T Goto; K Kishibe; M Takahara; Y Harabuchi
Journal:  Clin Exp Immunol       Date:  2009-07       Impact factor: 4.330
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