Literature DB >> 10438056

Synthesis and immunologic characterisation of Mycobacterium tuberculosis lipoarabinomannan specific oligosaccharide-protein conjugates.

B Hamasur1, G Källenius, S B Svenson.   

Abstract

Lipoarabinomannan (LAM) is a major structural surface component of all mycobacteria, and has been reported to have a wide range of biological effects. Immunogenic LAM specific oligosaccharide protein conjugates were synthesized and immunologically characterized. Oligosaccharides were derived from LAM purified from Mycobacterium tuberculosis H37 Rv and covalently conjugated to tetanus toxoid and cross reactive mutant (CRM197) diphtheria toxoid. Both types of LAM oligosaccharide protein conjugates proved to be highly immunogenic, inducing a boosterable T helper cell dependent IgG response. These conjugates are currently evaluated as components in a subcellular experimental TB vaccine.

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Year:  1999        PMID： 10438056     DOI： 10.1016/s0264-410x(99)00124-3

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  7 in total

Review 1.  Do CD1-restricted T cells contribute to antibody-mediated immunity against Mycobacterium tuberculosis?

Authors:  Mark L Lang; Aharona Glatman-Freedman
Journal:  Infect Immun       Date:  2006-02       Impact factor: 3.441

Review 2.  Updates on antibody functions in Mycobacterium tuberculosis infection and their relevance for developing a vaccine against tuberculosis.

Authors:  Jacqueline M Achkar; Rafael Prados-Rosales
Journal:  Curr Opin Immunol       Date:  2018-04-12       Impact factor: 7.486

3.  Expression of a Mycobacterium tuberculosis arabinomannan antigen in vitro and in vivo.

Authors:  J R Schwebach; A Casadevall; R Schneerson; Z Dai; X Wang; J B Robbins; A Glatman-Freedman
Journal:  Infect Immun       Date:  2001-09       Impact factor: 3.441

4.  Synthesis and immunogenicity of the Mycobacterium tuberculosis arabinomannan-CRM197 conjugate.

Authors:  Yunsong Chang; Xin Meng; Yaxin Li; Jianmei Liang; Tingshen Li; Demei Meng; Tao Zhu; Peng Yu
Journal:  Medchemcomm       Date:  2019-04-02       Impact factor: 3.597

5.  A mycobacterial lipoarabinomannan specific monoclonal antibody and its F(ab') fragment prolong survival of mice infected with Mycobacterium tuberculosis.

Authors:  B Hamasur; M Haile; A Pawlowski; U Schroder; G Kallenius; S B Svenson
Journal:  Clin Exp Immunol       Date:  2004-10       Impact factor: 4.330

6.  Enhanced control of Mycobacterium tuberculosis extrapulmonary dissemination in mice by an arabinomannan-protein conjugate vaccine.

Authors:  Rafael Prados-Rosales; Leandro Carreño; Tingting Cheng; Caroline Blanc; Brian Weinrick; Adel Malek; Todd L Lowary; Andres Baena; Maju Joe; Yu Bai; Rainer Kalscheuer; Ana Batista-Gonzalez; Noemi A Saavedra; Leticia Sampedro; Julen Tomás; Juan Anguita; Shang-Cheng Hung; Ashish Tripathi; Jiayong Xu; Aharona Glatman-Freedman; Williams R Jacobs; John Chan; Steven A Porcelli; Jacqueline M Achkar; Arturo Casadevall
Journal:  PLoS Pathog       Date:  2017-03-09       Impact factor: 6.823

Review 7.  Lipoarabinomannan in Active and Passive Protection Against Tuberculosis.

Authors:  Margarida Correia-Neves; Christopher Sundling; Andrea Cooper; Gunilla Källenius
Journal:  Front Immunol       Date:  2019-09-11       Impact factor: 7.561
  7 in total

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