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Literature DB >> 10437877

Relief from profound fatigue associated with chronic liver disease by long-term ondansetron therapy.

Abstract

A woman with chronic hepatitis C and profound fatigue became symptomfree when treated long-term with ondansetron 4 mg twice daily. Altered central serotoninergic neurotransmission may contribute to fatigue complicating chronic liver disease.

Entities: Chemical Disease Species

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Year: 1999 PMID： 10437877 DOI： 10.1016/S0140-6736(99)02936-0

Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321

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Cited

14 in total

Review 1. The central opioid system in liver disease and its complications.

Authors: C Yurdaydin
Journal: Metab Brain Dis Date: 2001-06 Impact factor: 3.584

2. 5-HT3 receptor antagonists ameliorate fatigue: so much potential, so little knowledge!

Authors: N M Barnes
Journal: Gut Date: 2005-08 Impact factor: 23.059

3. Monoaminergic neurotransmission is altered in hepatitis C virus infected patients with chronic fatigue and cognitive impairment.

Authors: K Weissenborn; J C Ennen; M Bokemeyer; B Ahl; U Wurster; H Tillmann; C Trebst; H Hecker; G Berding
Journal: Gut Date: 2006-05-08 Impact factor: 23.059

4. Effect of ondansetron, a 5-HT3 receptor antagonist, on fatigue in chronic hepatitis C: a randomised, double blind, placebo controlled study.

Authors: T Piche; G Vanbiervliet; F Cherikh; Z Antoun; P M Huet; E Gelsi; J-F Demarquay; F-X Caroli-Bosc; S Benzaken; M-C Rigault; C Renou; P Rampal; A Tran
Journal: Gut Date: 2005-08 Impact factor: 23.059

Relief from profound fatigue associated with chronic liver disease by long-term ondansetron therapy.

Review 1. The central opioid system in liver disease and its complications.

2. 5-HT3 receptor antagonists ameliorate fatigue: so much potential, so little knowledge!

3. Monoaminergic neurotransmission is altered in hepatitis C virus infected patients with chronic fatigue and cognitive impairment.

4. Effect of ondansetron, a 5-HT3 receptor antagonist, on fatigue in chronic hepatitis C: a randomised, double blind, placebo controlled study.

5. Management of Adverse Events During the Treatment of Chronic Hepatitis C Infection.

6. Fluoxetine for the treatment of fatigue in primary biliary cirrhosis: a randomized, double-blind controlled trial.

Review 7. Pruritus: management algorithms and experimental therapies.

Review 8. The neurosteroid system: an emerging therapeutic target for hepatic encephalopathy.

Review 9. Hepatitis C virus infection and the brain.

Review 10. Fatigue in liver disease: pathophysiology and clinical management.