Literature DB >> 10437805

Metabolism of progesterone to DOC, corticosterone and 18OHDOC in cultured human melanoma cells.

A Slominski1, C E Gomez-Sanchez, M F Foecking, J Wortsman.   

Abstract

We are now showing that cultured human melanoma cells can synthesize steroids such as corticosterone from progesterone or deoxycorticosterone. Corticosterone production is strongly responsive to deoxycorticosterone substrate addition (12-fold increase), but unresponsive to the adrenal stimulating factors ACTH and angiotensin II. This is the first demonstration that skin cells (malignant melanocytes) have the capability to synthesize 11-deoxycorticosterone, corticosterone, and 18-hydroxydeoxycorticosterone.

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Year:  1999        PMID： 10437805     DOI： 10.1016/s0014-5793(99)00889-3

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  30 in total

Review 1.  Immunomodulatory effects of sex hormones: requirements for pregnancy and relevance in melanoma.

Authors:  Elizabeth Ann L Enninga; Shernan G Holtan; Douglas J Creedon; Roxana S Dronca; Wendy K Nevala; Simona Ognjanovic; Svetomir N Markovic
Journal:  Mayo Clin Proc       Date:  2014-04       Impact factor: 7.616

2.  Targeted skin overexpression of the mineralocorticoid receptor in mice causes epidermal atrophy, premature skin barrier formation, eye abnormalities, and alopecia.

Authors:  Yannis Sainte Marie; Antoine Toulon; Ralf Paus; Eve Maubec; Aicha Cherfa; Maggy Grossin; Vincent Descamps; Maud Clemessy; Jean-Marie Gasc; Michel Peuchmaur; Adam Glick; Nicolette Farman; Frederic Jaisser
Journal:  Am J Pathol       Date:  2007-08-03       Impact factor: 4.307

Review 3.  Neuroendocrine system of the skin.

Authors:  Andrzej Slominski
Journal:  Dermatology       Date:  2005       Impact factor: 5.366

4.  Topical Mineralocorticoid Receptor Blockade Limits Glucocorticoid-Induced Epidermal Atrophy in Human Skin.

Authors:  Eve Maubec; Cédric Laouénan; Lydia Deschamps; Van Tuan Nguyen; Isabelle Scheer-Senyarich; Anne-Catherine Wackenheim-Jacobs; Maud Steff; Stéphanie Duhamel; Sarah Tubiana; Nesrine Brahimi; Stéphanie Leclerc-Mercier; Béatrice Crickx; Claudine Perret; Selim Aractingi; Brigitte Escoubet; Xavier Duval; Philippe Arnaud; Frederic Jaisser; France Mentré; Nicolette Farman
Journal:  J Invest Dermatol       Date:  2015-02-10       Impact factor: 8.551

Review 5.  Corticotropin releasing hormone and the skin.

Authors:  Andrzej Slominski; Blazej Zbytek; Michal Zmijewski; Radomir M Slominski; Sobia Kauser; Jacobo Wortsman; Desmond J Tobin
Journal:  Front Biosci       Date:  2006-09-01

6.  Cultured human dermal fibroblasts do produce cortisol.

Authors:  Andrzej Slominski; Blazej Zbytek; Andrzej Szczesniewski; Jacobo Wortsman
Journal:  J Invest Dermatol       Date:  2006-05       Impact factor: 8.551

7.  Skin as an endocrine organ: implications for its function.

Authors:  Andrzej Slominski; Jacobo Wortsman; Ralf Paus; Peter M Elias; Desmond J Tobin; Kenneth R Feingold
Journal:  Drug Discov Today Dis Mech       Date:  2008-06-01

8.  Hair cortisol: a parameter of chronic stress? Insights from a radiometabolism study in guinea pigs.

Authors:  Karin Keckeis; Michael Lepschy; Hanna Schöpper; Lukas Moser; Josef Troxler; Rupert Palme
Journal:  J Comp Physiol B       Date:  2012-05-17       Impact factor: 2.200

9.  Neuroendocrinology of the skin: An overview and selective analysis.

Authors:  Michal A Zmijewski; Andrzej T Slominski
Journal:  Dermatoendocrinol       Date:  2011-01

Review 10.  Steroidogenesis in the skin: implications for local immune functions.

Authors:  Andrzej Slominski; Blazej Zbytek; Georgios Nikolakis; Pulak R Manna; Cezary Skobowiat; Michal Zmijewski; Wei Li; Zorica Janjetovic; Arnold Postlethwaite; Christos C Zouboulis; Robert C Tuckey
Journal:  J Steroid Biochem Mol Biol       Date:  2013-02-19       Impact factor: 4.292
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