OBJECTIVE: To evaluate the effects of desmopressin on pressure values inside the pelvis and ureter of the rat following acute obstruction. MATERIALS AND METHODS: By means of a microsurgical technique, 24 male Wistar rats were submitted to ureteral obstruction; pressure inside the ureter was recorded using a cannula and a micrometric glass column. In the treatment group (14 animals) 6 mg/kg of desmopressin were administered 30 min before the beginning of the experiment. RESULTS: Rats pretreated with desmopressin showed a statistically significant reduction in mean intraureteral pressure following acute obstruction (p = 0.05). CONCLUSIONS: In Wistar rats desmopressin demonstrated a powerful antidiuretic effect, reducing the intraureteral pressure. The experimental model is useful for a better understanding of physiopathology of renal colic and acute obstruction.
OBJECTIVE: To evaluate the effects of desmopressin on pressure values inside the pelvis and ureter of the rat following acute obstruction. MATERIALS AND METHODS: By means of a microsurgical technique, 24 male Wistar rats were submitted to ureteral obstruction; pressure inside the ureter was recorded using a cannula and a micrometric glass column. In the treatment group (14 animals) 6 mg/kg of desmopressin were administered 30 min before the beginning of the experiment. RESULTS:Rats pretreated with desmopressin showed a statistically significant reduction in mean intraureteral pressure following acute obstruction (p = 0.05). CONCLUSIONS: In Wistar rats desmopressin demonstrated a powerful antidiuretic effect, reducing the intraureteral pressure. The experimental model is useful for a better understanding of physiopathology of renal colic and acute obstruction.
Authors: Catalin Pricop; Dumitru D Branisteanu; Martha Orsolya; Dragos Puia; Anca Matei; Ionel Alexandru Checherita Journal: Int Urol Nephrol Date: 2015-12-16 Impact factor: 2.370