Molecular basis of drug recognition by specific T-cell receptors.

In recent years the involvement of T cells in allergic reactions to drugs has been well established. However, several molecular aspects of drug recognition by specific T cells remain still unclear. This review will discuss the known pathways of drug presentations by antigen presenting cells, the recognition of MHC/peptide/drug complexes by specific T-cell receptors, and the activation mechanism of drug-specific T cells.