Literature DB >> 10436385

Heterogeneity for multiple disease loci in linkage analysis.

A Bhat1, S C Heath, J Ott.   

Abstract

Many mendelian traits show heterogeneity; that is, the disease phenotype in different families may be caused by genes at different locations. In linkage analysis, this admixture type of heterogeneity (locus heterogeneity) has often been accommodated with one of the HOMOG programs, which thus far have been restricted to at most two disease gene locations. Here, an extension to an arbitrary number of disease locations is described. It has been implemented in a computer program, HOMOGM. This approach is also suitable as an approximation to the situation of complex traits, in which multiple disease genes may occur in the same family.

Mesh：

Year:  1999        PMID： 10436385     DOI： 10.1159/000022879

Source DB:  PubMed          Journal:  Hum Hered        ISSN： 0001-5652            Impact factor:   0.444


  10 in total

1.  Regression models for linkage heterogeneity applied to familial prostate cancer.

Authors:  D J Schaid; S K McDonnell; S N Thibodeau
Journal:  Am J Hum Genet       Date:  2001-04-13       Impact factor: 11.025

2.  Ordered-subset analysis (OSA) for family-based association mapping of complex traits.

Authors:  Ren-Hua Chung; Silke Schmidt; Eden R Martin; Elizabeth R Hauser
Journal:  Genet Epidemiol       Date:  2008-11       Impact factor: 2.135

3.  Identification, by homozygosity mapping, of a novel locus for autosomal recessive congenital ichthyosis on chromosome 17p, and evidence for further genetic heterogeneity.

Authors:  A Krebsová; W Küster; G G Lestringant; B Schulze; B Hinz; P M Frossard; A Reis; H C Hennies
Journal:  Am J Hum Genet       Date:  2001-06-07       Impact factor: 11.025

4.  Two new loci for autosomal recessive ichthyosis on chromosomes 3p21 and 19p12-q12 and evidence for further genetic heterogeneity.

Authors:  J Fischer; A Faure; B Bouadjar; C Blanchet-Bardon; A Karaduman; I Thomas; S Emre; S Cure; M Ozgüc; J Weissenbach; J F Prud'homme
Journal:  Am J Hum Genet       Date:  2000-03       Impact factor: 11.025

5.  Attention-deficit/hyperactivity disorder in a population isolate: linkage to loci at 4q13.2, 5q33.3, 11q22, and 17p11.

Authors:  Mauricio Arcos-Burgos; F Xavier Castellanos; David Pineda; Francisco Lopera; Juan David Palacio; Luis Guillermo Palacio; Judith L Rapoport; Kate Berg; Joan E Bailey-Wilson; Maximilian Muenke
Journal:  Am J Hum Genet       Date:  2004-10-20       Impact factor: 11.025

6.  Linkage and association study of late-onset Alzheimer disease families linked to 9p21.3.

Authors:  S Züchner; J R Gilbert; E R Martin; C R Leon-Guerrero; P-T Xu; C Browning; P G Bronson; P Whitehead; D E Schmechel; J L Haines; M A Pericak-Vance
Journal:  Ann Hum Genet       Date:  2008-08-28       Impact factor: 1.670

7.  Chromosomes 4 and 8 implicated in a genome wide SNP linkage scan of 762 prostate cancer families collected by the ICPCG.

Authors:  Lingyi Lu; Geraldine Cancel-Tassin; Antoine Valeri; Olivier Cussenot; Ethan M Lange; Kathleen A Cooney; James M Farnham; Nicola J Camp; Lisa A Cannon-Albright; Teuvo L J Tammela; Johanna Schleutker; Josef Hoegel; Kathleen Herkommer; Christiane Maier; Walther Vogel; Fredrik Wiklund; Monica Emanuelsson; Henrik Grönberg; Kathleen E Wiley; Sarah D Isaacs; Patrick C Walsh; Brian T Helfand; Donghui Kan; William J Catalona; Janet L Stanford; Liesel M FitzGerald; Bo Johanneson; Kerry Deutsch; Laura McIntosh; Elaine A Ostrander; Stephen N Thibodeau; Shannon K McDonnell; Scott Hebbring; Daniel J Schaid; Alice S Whittemore; Ingrid Oakley-Girvan; Chih-Lin Hsieh; Isaac Powell; Joan E Bailey-Wilson; Cheryl D Cropp; Claire Simpson; John D Carpten; Daniela Seminara; S Lilly Zheng; Jianfen Xu; Graham G Giles; Gianluca Severi; John L Hopper; Dallas R English; William D Foulkes; Lovise Maehle; Pal Moller; Michael D Badzioch; Steve Edwards; Michelle Guy; Ros Eeles; Douglas Easton; William B Isaacs
Journal:  Prostate       Date:  2011-07-11       Impact factor: 4.104

8.  TDT-HET: a new transmission disequilibrium test that incorporates locus heterogeneity into the analysis of family-based association data.

Authors:  Douglas Londono; Steven Buyske; Stephen J Finch; Swarkar Sharma; Carol A Wise; Derek Gordon
Journal:  BMC Bioinformatics       Date:  2012-01-20       Impact factor: 3.169

9.  Analysis of genes for alcoholism using two-disease-locus models.

Authors:  Chih-Chieh Wu; Sanjay Shete
Journal:  BMC Genet       Date:  2005-12-30       Impact factor: 2.797

10.  KIAA1462, a coronary artery disease associated gene, is a candidate gene for late onset Alzheimer disease in APOE carriers.

Authors:  Deborah G Murdock; Yuki Bradford; Nathalie Schnetz-Boutaud; Ping Mayo; Melissa J Allen; Laura N D'Aoust; Xueying Liang; Sabrina L Mitchell; Stephan Zuchner; Gary W Small; John R Gilbert; Margaret A Pericak-Vance; Jonathan L Haines
Journal:  PLoS One       Date:  2013-12-12       Impact factor: 3.240
  10 in total

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