| Literature DB >> 10434047 |
H H Ko1, J J Wang, H C Lin, J P Wang, C N Lin.
Abstract
A novel constituent named australone B (1) was further isolated from the cortex of Morus australis (Moraceae). The structure of 1 has been elucidated by one- and two-dimension spectra. In human citrated platelet-rich plasma, 1 showed strong inhibition of aggregation induced by adrenaline in a concentration-dependent manner with an IC(50) value of about 33.3 microM. Compound 1 (30 microM) also showed inhibitory effects on superoxide anion formation from rat neutrophils stimulated with formyl-Met-Leu-Phe (fMLP)/cytochalasin B (CB). Morusin (2) inhibited superoxide anion formation from rat neutrophils stimulated with phorbol myristate acetate (PMA) in a concentration-dependent manner with an IC(50) value of 66.9+/-2.5 microM.Entities:
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Year: 1999 PMID： 10434047 DOI： 10.1016/s0304-4165(99)00084-7
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002