Literature DB >> 10433385

The aging paradox: free radical theory of aging.

B T Ashok1, R Ali.   

Abstract

There are more than 300 theories to explain the aging phenomenon. Many of them originate from the study of changes that accumulate with time. Among all the theories, the free radical theory of aging, postulated first by Harman, is the most popular and widely tested, and is based on the chemical nature and ubiquitous presence of free radicals. This review aims to recapitulate various studies on the role of free radicals in DNA damage-both nuclear as well as mitochondrial-the oxidative stress they impose on cells, the role of antioxidants, the presence of autoantibodies, and their overall impact on the aging process.

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Year:  1999        PMID： 10433385     DOI： 10.1016/s0531-5565(99)00005-4

Source DB:  PubMed          Journal:  Exp Gerontol        ISSN： 0531-5565            Impact factor:   4.032


  39 in total

1.  Quantitative proteomic profiling of muscle type-dependent and age-dependent protein carbonylation in rat skeletal muscle mitochondria.

Authors:  Juan Feng; Hongwei Xie; Danni L Meany; Ladora V Thompson; Edgar A Arriaga; Timothy J Griffin
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2008-11       Impact factor: 6.053

Review 2.  Genetic epidemiology in aging research.

Authors:  M Daniele Fallin; Amy Matteini
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2009-01-23       Impact factor: 6.053

Review 3.  Redox Systems Biology: Harnessing the Sentinels of the Cysteine Redoxome.

Authors:  Jason M Held
Journal:  Antioxid Redox Signal       Date:  2019-09-09       Impact factor: 8.401

Review 4.  Nitrone-based therapeutics for neurodegenerative diseases: their use alone or in combination with lanthionines.

Authors:  Robert A Floyd; Hugo C Castro Faria Neto; Guy A Zimmerman; Kenneth Hensley; Rheal A Towner
Journal:  Free Radic Biol Med       Date:  2013-02-16       Impact factor: 7.376

5.  Oxidative stress in older adults: effects of physical fitness.

Authors:  Tinna Traustadóttir; Sean S Davies; Yali Su; Leena Choi; Holly M Brown-Borg; L Jackson Roberts; S Mitchell Harman
Journal:  Age (Dordr)       Date:  2011-06-14

6.  Antioxidant potential, paraoxonase 1, ceruloplasmin activity and C-reactive protein concentration in diabetic retinopathy.

Authors:  Mariusz Nowak; Tomasz Wielkoszyński; Bogdan Marek; Beata Kos-Kudła; Elzbieta Swietochowska; Lucyna Siemińska; Jacek Karpe; Dariusz Kajdaniuk; Joanna Głogowska-Szelag; Katarzyna Nowak
Journal:  Clin Exp Med       Date:  2009-12-11       Impact factor: 3.984

7.  Physiological and morphological changes in autolyzing Aspergillus nidulans cultures.

Authors:  T Emri; Z Molnár; T Pusztahelyi; I Pócsi
Journal:  Folia Microbiol (Praha)       Date:  2004       Impact factor: 2.099

8.  Analysis of Nucleosides in Municipal Wastewater by Large-Volume Liquid Chromatography Tandem Mass Spectrometry.

Authors:  Alex J Brewer; Craig Lunte
Journal:  Anal Methods       Date:  2015-07-07       Impact factor: 2.896

9.  Tart cherry juice decreases oxidative stress in healthy older men and women.

Authors:  Tinna Traustadóttir; Sean S Davies; Anthoney A Stock; Yali Su; Christopher B Heward; L Jackson Roberts; S Mitchell Harman
Journal:  J Nutr       Date:  2009-08-19       Impact factor: 4.798

10.  GIN'n'CIN hypothesis of brain aging: deciphering the role of somatic genetic instabilities and neural aneuploidy during ontogeny.

Authors:  Yuri B Yurov; Svetlana G Vorsanova; Ivan Y Iourov
Journal:  Mol Cytogenet       Date:  2009-11-25       Impact factor: 2.009
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