| Literature DB >> 10432707 |
J Machado1, H Salomon, M Oliveira, C Tsoukas, A A Krayevsky, M A Wainberg.
Abstract
Both AZT and its novel 5'-hydrogen phosphonate derivative, Phosphazid, possess similar in vitro activity and resistance profiles. Experiments involving AZT-resistant virus isolates revealed a strong correlation between resistance to AZT and cross-resistance to Phosphazid. In vitro selection for resistance to Phosphazid yielded viruses that were about 15-fold less sensitive than wild-type virus to this drug. Sequencing of the reverse transcriptase region of seven Phosphazid-selected viruses revealed a single codon mutation, D67N, that is associated with resistance to AZT.Entities:
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Year: 1999 PMID： 10432707 DOI： 10.1080/15257779908041597
Source DB: PubMed Journal: Nucleosides Nucleotides ISSN： 0732-8311