Literature DB >> 10432694

Derivatives of L-adenosine and L-guanosine as substrates for human deoxycytidine kinase.

G Gaubert1, G Gosselin, J L Imbach, S Eriksson, G Maury.   

Abstract

A series of analogues of L-adenosine and of L-guanosine, including beta-L-dA, beta-L-Ado, beta-L-araA, and beta-L-dG, have been shown to be substrates of human deoxycytidine kinase thus demonstrating the complete lack of enantioselectivity of this enzyme.

Entities:  

Mesh:

Substances:

Year:  1999        PMID: 10432694     DOI: 10.1080/15257779908041581

Source DB:  PubMed          Journal:  Nucleosides Nucleotides        ISSN: 0732-8311


  1 in total

1.  Nonenantioselectivity property of human deoxycytidine kinase explained by structures of the enzyme in complex with L- and D-nucleosides.

Authors:  Elisabetta Sabini; Saugata Hazra; Manfred Konrad; Arnon Lavie
Journal:  J Med Chem       Date:  2007-05-27       Impact factor: 7.446

  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.