| Literature DB >> 10431834 |
E Straface1, B Natalini, D Monti, C Franceschi, G Schettini, M Bisaglia, C Fumelli, C Pincelli, R Pellicciari, W Malorni.
Abstract
Anoikia is a type of apoptotic cell death that occurs in cells that are substrate-restricted in their growth. Buckminsterfullerenes represent a new class of chemical compounds with wide potential pharmacological antioxidant activity. In this report we provide the first demonstration that a water-soluble fullerene derivative, C3-fullero-tris-methanodicarboxylic acid, synthesized in our laboratories, is capable of inducing anoikia resistance in epithelial cells by a mechanism involving a 'trophic' effect on cell spreading-associated cytoskeletal components, i.e. on actin microfilaments.Entities:
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Year: 1999 PMID： 10431834 DOI： 10.1016/s0014-5793(99)00812-1
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124