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Literature DB >> 10431187

Host resistance to infection: genetic control of lipopolysaccharide responsiveness by TOLL-like receptor genes.

Abstract

Gram-negative bacterial lipopolysaccharide evokes a protective inflammatory response in the normal host. Through genetic analysis of mutant mice, the gene encoding Toll-like receptor 4 (Tlr4) was recently identified as a critical component of this host defense mechanism. Tlr4 is a member of an ancient gene family that regulates antimicrobial host defense in plants, invertebrates and mammals.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1999 PMID： 10431187 DOI： 10.1016/s0168-9525(99)01782-5

Source DB: PubMed Journal: Trends Genet ISSN： 0168-9525 Impact factor: 11.639

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Cited

23 in total

Review 1. Toll-like receptors: molecular mechanisms of the mammalian immune response.

Authors: H D Brightbill; R L Modlin
Journal: Immunology Date: 2000-09 Impact factor: 7.397

Review 2. Defense of the bovine mammary gland by polymorphonuclear neutrophil leukocytes.

Authors: Max Paape; Jalil Mehrzad; Xin Zhao; Johann Detilleux; Christian Burvenich
Journal: J Mammary Gland Biol Neoplasia Date: 2002-04 Impact factor: 2.673

3. Annotation of a 95-kb Populus deltoides genomic sequence reveals a disease resistance gene cluster and novel class I and class II transposable elements.

Authors: M Lescot; S Rombauts; J Zhang; S Aubourg; C Mathé; S Jansson; P Rouzé; W Boerjan
Journal: Theor Appl Genet Date: 2004-04-14 Impact factor: 5.699

Review 4. The proteasome: a central regulator of inflammation and macrophage function.

Authors: Nilofer Qureshi; Stefanie N Vogel; Charles Van Way; Christopher J Papasian; Asaf A Qureshi; David C Morrison
Journal: Immunol Res Date: 2005 Impact factor: 2.829

5. Differential expression of toll-like receptor 3 and 5 in ileal pouch mucosa of ulcerative colitis patients.

Authors: Gundi Heuschen; Christine Leowardi; Ulf Hinz; Frank Autschbach; Andreas Stallmach; Christian Herfarth; Udo A Heuschen
Journal: Int J Colorectal Dis Date: 2006-06-13 Impact factor: 2.571

6. Critical role of CD14 for production of proinflammatory cytokines and cytokine inhibitors during sepsis with failure to alter morbidity or mortality.

Authors: S J Ebong; S M Goyert; J A Nemzek; J Kim; G L Bolgos; D G Remick
Journal: Infect Immun Date: 2001-04 Impact factor: 3.441

Host resistance to infection: genetic control of lipopolysaccharide responsiveness by TOLL-like receptor genes.

Review 1. Toll-like receptors: molecular mechanisms of the mammalian immune response.

Review 2. Defense of the bovine mammary gland by polymorphonuclear neutrophil leukocytes.

3. Annotation of a 95-kb Populus deltoides genomic sequence reveals a disease resistance gene cluster and novel class I and class II transposable elements.

Review 4. The proteasome: a central regulator of inflammation and macrophage function.

5. Differential expression of toll-like receptor 3 and 5 in ileal pouch mucosa of ulcerative colitis patients.

6. Critical role of CD14 for production of proinflammatory cytokines and cytokine inhibitors during sepsis with failure to alter morbidity or mortality.

7. Krüppel-like factor 4, a novel transcription factor regulates microglial activation and subsequent neuroinflammation.

Review 8. Mouse mammary tumor virus and the immune system.

Review 9. Receptors, mediators, and mechanisms involved in bacterial sepsis and septic shock.

10. Protective effects of Lactobacillus plantarum NDC 75017 against lipopolysaccharide-induced liver injury in mice.