Literature DB >> 10431158

The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction.

M L Lupher1, N Rao, M J Eck, H Band.   

Abstract

The Cbl protooncoprotein has recently emerged as a component of tyrosine kinase-mediated signal transduction in a variety of cell types. Here, we discuss evidence that supports a role for Cbl as a novel negative regulator of immune receptor signaling, and present models for its mode of function.

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Year:  1999        PMID: 10431158     DOI: 10.1016/s0167-5699(99)01484-x

Source DB:  PubMed          Journal:  Immunol Today        ISSN: 0167-5699


  25 in total

1.  The Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation.

Authors:  C E Andoniou; N L Lill; C B Thien; M L Lupher; S Ota; D D Bowtell; R M Scaife; W Y Langdon; H Band
Journal:  Mol Cell Biol       Date:  2000-02       Impact factor: 4.272

2.  The non-receptor tyrosine kinase Syk is a target of Cbl-mediated ubiquitylation upon B-cell receptor stimulation.

Authors:  N Rao; A K Ghosh; S Ota; P Zhou; A L Reddi; K Hakezi; B K Druker; J Wu; H Band
Journal:  EMBO J       Date:  2001-12-17       Impact factor: 11.598

3.  Negative regulation of Lck by Cbl ubiquitin ligase.

Authors:  Navin Rao; Sachiko Miyake; Alagarsamy Lakku Reddi; Patrice Douillard; Amiya K Ghosh; Ingrid L Dodge; Pengcheng Zhou; Norvin D Fernandes; Hamid Band
Journal:  Proc Natl Acad Sci U S A       Date:  2002-03-19       Impact factor: 11.205

4.  Oncogenic Signaling by Leukemia-Associated Mutant Cbl Proteins.

Authors:  Scott Nadeau; Wei An; Nick Palermo; Dan Feng; Gulzar Ahmad; Lin Dong; Gloria E O Borgstahl; Amarnath Natarajan; Mayumi Naramura; Vimla Band; Hamid Band
Journal:  Biochem Anal Biochem       Date:  2012-07-30

Review 5.  T-helper cell intrinsic defects in lupus that break peripheral tolerance to nuclear autoantigens.

Authors:  Syamal K Datta; Li Zhang; Luting Xu
Journal:  J Mol Med (Berl)       Date:  2005-01-04       Impact factor: 4.599

6.  An essential role of ubiquitination in Cbl-mediated negative regulation of the Src-family kinase Fyn.

Authors:  Navin Rao; Amiya K Ghosh; Patrice Douillard; Christopher E Andoniou; Pengcheng Zhou; Hamid Band
Journal:  Signal Transduct       Date:  2002-11-07

7.  Efficient generation of useful monoclonal antibodies reactive with globotriaosylceramide using knockout mice lacking Gb3/CD77 synthase.

Authors:  Yuji Kondo; Noriyo Tokuda; Keiko Furukawa; Reiko Ando; Makoto Uchikawa; Qing Zhang; Fan Xiaoyan; Koichi Furukawa
Journal:  Glycoconj J       Date:  2011-06-10       Impact factor: 2.916

8.  Superantigen-induced CD4 memory T cell anergy. I. Staphylococcal enterotoxin B induces Fyn-mediated negative signaling.

Authors:  Andrew R O Watson; David K Janik; William T Lee
Journal:  Cell Immunol       Date:  2012-02-17       Impact factor: 4.868

9.  Alpha-MSH regulates protein ubiquitination in T cells.

Authors:  D J Biros; K Namba; A W Taylor
Journal:  Cell Mol Biol (Noisy-le-grand)       Date:  2006-05-30       Impact factor: 1.770

10.  Selective abolition of pancreatic RNase binding to its inhibitor protein.

Authors:  Kapil Kumar; Michael Brady; Robert Shapiro
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-17       Impact factor: 11.205

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