Literature DB >> 10431147

Visual exploration of HTS databases: bridging the gap between chemistry and biology.

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Abstract

As pharmaceutical corporations are under pressure to shorten research and development (R&D) cycles for new drugs, novel technologies are being deployed, producing a data explosion in the research environment. Researchers can then become the bottleneck in the R&D cycle when they are unable to analyze data quickly enough. To deliver on the promise of these high-throughput technologies, pharmaceutical R&D must introduce novel decision support systems to support the mantra of R&D decision support: access, analyze and publish.

Entities:  

Year:  1999        PMID: 10431147     DOI: 10.1016/s1359-6446(99)01373-2

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN: 1359-6446            Impact factor:   7.851


  6 in total

1.  Bottlenecks caused by software gaps in miRNA and RNAi research.

Authors:  Sean Ekins; Ron Shigeta; Barry A Bunin
Journal:  Pharm Res       Date:  2012-02-24       Impact factor: 4.200

2.  ADAAPT: Amgen's data access, analysis, and prediction tools.

Authors:  Sung Jin Cho; Yaxiong Sun; William Harte
Journal:  J Comput Aided Mol Des       Date:  2006-06-21       Impact factor: 3.686

Review 3.  In silico pharmacology for drug discovery: methods for virtual ligand screening and profiling.

Authors:  S Ekins; J Mestres; B Testa
Journal:  Br J Pharmacol       Date:  2007-06-04       Impact factor: 8.739

4.  High-throughput screening uncovers a compound that activates latent HIV-1 and acts cooperatively with a histone deacetylase (HDAC) inhibitor.

Authors:  Sofiya Micheva-Viteva; Yoshifumi Kobayashi; Leonard C Edelstein; Annmarie L Pacchia; Hui-Ling Rose Lee; Jason D Graci; Jamie Breslin; Bradley D Phelan; Leia K Miller; Joseph M Colacino; Zhengxian Gu; Yacov Ron; Stuart W Peltz; Joseph P Dougherty
Journal:  J Biol Chem       Date:  2011-04-15       Impact factor: 5.157

5.  Extracting SAR Information from a Large Collection of Anti-Malarial Screening Hits by NSG-SPT Analysis.

Authors:  Mathias Wawer; Jürgen Bajorath
Journal:  ACS Med Chem Lett       Date:  2011-01-05       Impact factor: 4.345

Review 6.  New strategies in drug discovery.

Authors:  Eliot H Ohlstein; Anthony G Johnson; John D Elliott; Anne M Romanic
Journal:  Methods Mol Biol       Date:  2006
  6 in total

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