Literature DB >> 10428979

A new 6-hydroxy-4-sphingenine-containing ceramide in human skin.

M E Stewart1, D T Downing.   

Abstract

A new ceramide consisting of 6-hydroxysphingosine linked to a non-hydroxyacid was found in human epidermal lipid. This ceramide was sought because its fatty acid and sphingoid moieties are present in other combinations in human epidermal ceramides. To isolate the new ceramide, the mixture of ceramides in human epidermal lipid was first separated into fractions by thin-layer chromatography (TLC), and then each fraction was further purified by TLC after acetylation of all hydroxyl groups. TLC after acetylation revealed that one of the fractions isolated in the first TLC step contained two components, namely, the ceramide consisting of sphingosine linked to an alpha-hydroxyacid and an unknown ceramide. The new ceramide constituted about 9% of the total ceramides, and was shown by NMR spectroscopy to be N-acyl-6-hydroxysphingosine.

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Year:  1999        PMID： 10428979

Source DB:  PubMed          Journal:  J Lipid Res        ISSN： 0022-2275            Impact factor:   5.922


  18 in total

Review 1.  Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics.

Authors:  Alfred H Merrill
Journal:  Chem Rev       Date:  2011-09-26       Impact factor: 60.622

2.  Loss of functional ELOVL4 depletes very long-chain fatty acids (> or =C28) and the unique omega-O-acylceramides in skin leading to neonatal death.

Authors:  Vidyullatha Vasireddy; Yoshikazu Uchida; Norman Salem; Soo Yeon Kim; Md Nawajesh Ali Mandal; Geereddy Bhanuprakash Reddy; Ravi Bodepudi; Nathan L Alderson; Johnie C Brown; Hiroko Hama; Andrzej Dlugosz; Peter M Elias; Walter M Holleran; Radha Ayyagari
Journal:  Hum Mol Genet       Date:  2007-01-05       Impact factor: 6.150

3.  Simulation study of the structure and phase behavior of ceramide bilayers and the role of lipid head group chemistry.

Authors:  Shan Guo; Timothy C Moore; Christopher R Iacovella; L Anderson Strickland; Clare McCabe
Journal:  J Chem Theory Comput       Date:  2013-11-12       Impact factor: 6.006

4.  LC/MS analysis of stratum corneum lipids: ceramide profiling and discovery.

Authors:  Jeroen van Smeden; Louise Hoppel; Rob van der Heijden; Thomas Hankemeier; Rob J Vreeken; Joke A Bouwstra
Journal:  J Lipid Res       Date:  2011-03-28       Impact factor: 5.922

5.  Anti-scratching behavioral effects of N-stearoyl-phytosphingosine and 4-hydroxysphinganine in mice.

Authors:  Kwon-Ryeol Ryu; Bomi Lee; In-Ah Lee; Sekwan Oh; Dong-Hyun Kim
Journal:  Lipids       Date:  2010-06-29       Impact factor: 1.880

6.  Complete structural characterization of ceramides as [M-H]- ions by multiple-stage linear ion trap mass spectrometry.

Authors:  Fong-Fu Hsu
Journal:  Biochimie       Date:  2016-08-12       Impact factor: 4.079

7.  Undulating tubular liposomes through incorporation of a synthetic skin ceramide into phospholipid bilayers.

Authors:  Peng Xu; Grace Tan; Jia Zhou; Jibao He; Louise B Lawson; Gary L McPherson; Vijay T John
Journal:  Langmuir       Date:  2009-09-15       Impact factor: 3.882

8.  The lipid organisation of the skin barrier: liquid and crystalline domains coexist in lamellar phases.

Authors:  J Bouwstra; G Gooris; M Ponec
Journal:  J Biol Phys       Date:  2002-06       Impact factor: 1.365

9.  Arrangement of ceramide [EOS] in a stratum corneum lipid model matrix: new aspects revealed by neutron diffraction studies.

Authors:  Doreen Kessner; Mikhail Kiselev; Silvia Dante; Thomas Hauss; Peter Lersch; Siegfried Wartewig; Reinhard H H Neubert
Journal:  Eur Biophys J       Date:  2008-04-22       Impact factor: 1.733

10.  Structural studies on ceramides as lithiated adducts by low energy collisional-activated dissociation tandem mass spectrometry with electrospray ionization.

Authors:  Fong-Fu Hsu; John Turk; Mary E Stewart; Donald T Downing
Journal:  J Am Soc Mass Spectrom       Date:  2002-06       Impact factor: 3.109
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