Literature DB >> 10428938

Identification of functional amino acids in the macrolide 2'-phosphotransferase II.

K Taniguchi1, A Nakamura, K Tsurubuchi, A Ishii, K O'Hara, T Sawai.   

Abstract

Macrolide 2'-phosphotransferase [MPH(2')] transfers the gamma phosphate of ATP to the 2'-OH group of macrolide antibiotics. The role of aspartic acids in the putative ATP-binding site of MPH(2')II was investigated through the substitution of alanine for aspartate by site-directed mutagenesis. D200A, D209A, D219A, and D231A mutant strains were unable to inactivate the substrate oleandomycin, while a D227A mutant retained 7% of the activity of the original enzyme.

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Year:  1999        PMID： 10428938      PMCID： PMC89416     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  22 in total

1.  Appearance in Japan of highly macrolide-resistant Escherichia coli producing macrolide 2'-phosphotransferase II.

Authors:  K Taniguchi; A Nakamura; K Tsurubuchi; A Ishii; K O'Hara; T Sawai
Journal:  Microbios       Date:  1999

2.  Site-specific mutations of conserved C-terminal residues in aminoglycoside 3'-phosphotransferase II: phenotypic and structural analysis of mutant enzymes.

Authors:  S Kocabiyik; M H Perlin
Journal:  Biochem Biophys Res Commun       Date:  1992-06-30       Impact factor: 3.575

3.  Structure-function analyses for aminoglycoside 3'-phosphotransferase II (APH(3')-II).

Authors:  S Kocabiyik; C Mullins; C Breeding; M H Perlin
Journal:  SAAS Bull Biochem Biotechnol       Date:  1992-01

4.  The rapid generation of oligonucleotide-directed mutations at high frequency using phosphorothioate-modified DNA.

Authors:  J W Taylor; J Ott; F Eckstein
Journal:  Nucleic Acids Res       Date:  1985-12-20       Impact factor: 16.971

5.  Purification and characterization of macrolide 2'-phosphotransferase from a strain of Escherichia coli that is highly resistant to erythromycin.

Authors:  K O'Hara; T Kanda; K Ohmiya; T Ebisu; M Kono
Journal:  Antimicrob Agents Chemother       Date:  1989-08       Impact factor: 5.191

6.  Epidemiology of intestinal colonization by members of the family Enterobacteriaceae highly resistant to erythromycin in a hematology-oncology unit.

Authors:  A Andremont; H Sancho-Garnier; C Tancrede
Journal:  Antimicrob Agents Chemother       Date:  1986-06       Impact factor: 5.191

7.  Contribution of two different mechanisms to erythromycin resistance in Escherichia coli.

Authors:  M Arthur; P Courvalin
Journal:  Antimicrob Agents Chemother       Date:  1986-11       Impact factor: 5.191

8.  Identification of Escherichia coli clinical isolates producing macrolide 2'-phosphotransferase by a highly sensitive detection method.

Authors:  K Taniguchi; A Nakamura; K Tsurubuchi; K O'Hara; T Sawai
Journal:  FEMS Microbiol Lett       Date:  1998-10-15       Impact factor: 2.742

9.  Altered substrate specificity by substitutions at Tyr218 in bacterial aminoglycoside 3'-phosphotransferase-II.

Authors:  S Kocabiyik; M H Perlin
Journal:  FEMS Microbiol Lett       Date:  1992-06-01       Impact factor: 2.742

10.  Distribution of erythromycin esterase and rRNA methylase genes in members of the family Enterobacteriaceae highly resistant to erythromycin.

Authors:  M Arthur; A Andremont; P Courvalin
Journal:  Antimicrob Agents Chemother       Date:  1987-03       Impact factor: 5.191
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  4 in total

1.  Detection and characterization of a macrolide 2'-phosphotransferase from a Pseudomonas aeruginosa clinical isolate.

Authors:  A Nakamura; I Miyakozawa; K Nakazawa; K O-Hara; T Sawai
Journal:  Antimicrob Agents Chemother       Date:  2000-11       Impact factor: 5.191

Review 2.  Resistance to tetracycline, macrolide-lincosamide-streptogramin, trimethoprim, and sulfonamide drug classes.

Authors:  Marilyn C Roberts
Journal:  Mol Biotechnol       Date:  2002-03       Impact factor: 2.695

Review 3.  Resistance to Macrolide Antibiotics in Public Health Pathogens.

Authors:  Corey Fyfe; Trudy H Grossman; Kathy Kerstein; Joyce Sutcliffe
Journal:  Cold Spring Harb Perspect Med       Date:  2016-10-03       Impact factor: 6.915

4.  Azithromycin resistance levels and mechanisms in Escherichia coli.

Authors:  Cláudia Gomes; Lidia Ruiz-Roldán; Judit Mateu; Theresa J Ochoa; Joaquim Ruiz
Journal:  Sci Rep       Date:  2019-04-15       Impact factor: 4.379
  4 in total

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