Literature DB >> 10428651

Human immunodeficiency virus type 1 protease inhibitor attenuates Candida albicans virulence properties in vitro.

A Gruber1, C Speth, E Lukasser-Vogl, R Zangerle, M Borg-von Zepelin, M P Dierich, R Würzner.   

Abstract

The putative virulence factor secreted aspartyl proteinase (SAP) of Candida albicans and the human immunodeficiency virus type 1 (HIV-1) protease both belong to the aspartyl proteinase family. The present study demonstrates that the HIV-1 protease inhibitor Indinavir is a weak but specific inhibitor of SAP. In addition, Indinavir reduces the amount of cell bound as well as released SAP antigen from C. albicans. Furthermore, viability and growth of C. albicans are markedly reduced by Indinavir. These findings indicate that HIV-1 protease inhibitors may possess antifungal activity and we speculate that in vivo SAP inhibition may add to the resolution of mucosal candidiasis in HIV-1 infected subjects.

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Year:  1999        PMID： 10428651     DOI： 10.1016/s0162-3109(99)00035-1

Source DB:  PubMed          Journal:  Immunopharmacology        ISSN： 0162-3109


  14 in total

1.  CD8 T cells and E-cadherin in host responses against oropharyngeal candidiasis.

Authors:  K Quimby; E A Lilly; M Zacharek; K McNulty; J E Leigh; J E Vazquez; P L Fidel
Journal:  Oral Dis       Date:  2011-09-30       Impact factor: 3.511

2.  Protease expression by microorganisms and its relevance to crucial physiological/pathological events.

Authors:  André Luis Souza Dos Santos
Journal:  World J Biol Chem       Date:  2011-03-26

Review 3.  Positive and negative aspects of the human immunodeficiency virus protease: development of inhibitors versus its role in AIDS pathogenesis.

Authors:  K Ikuta; S Suzuki; H Horikoshi; T Mukai; R B Luftig
Journal:  Microbiol Mol Biol Rev       Date:  2000-12       Impact factor: 11.056

Review 4.  Candida-host interactions in HIV disease: implications for oropharyngeal candidiasis.

Authors:  P L Fidel
Journal:  Adv Dent Res       Date:  2011-04

5.  Characterization of agglutinin-like sequence genes from non-albicans Candida and phylogenetic analysis of the ALS family.

Authors:  L L Hoyer; R Fundyga; J E Hecht; J C Kapteyn; F M Klis; J Arnold
Journal:  Genetics       Date:  2001-04       Impact factor: 4.562

6.  Repression of Proteases and Hsp90 Chaperone Expression Induced by an Antiretroviral in Virulent Environmental Strains of Cryptococcus neoformans.

Authors:  Cleber Fernando Serafin; Ana Paula Paris; Claudete Rodrigues Paula; Rita Cássia Garcia Simão; Rinaldo Ferreira Gandra
Journal:  Microb Ecol       Date:  2016-12-02       Impact factor: 4.552

7.  Tetracycline-inducible expression of individual secreted aspartic proteases in Candida albicans allows isoenzyme-specific inhibitor screening.

Authors:  Peter Staib; Ulrich Lermann; Julia Blass-Warmuth; Björn Degel; Reinhard Würzner; Michel Monod; Tanja Schirmeister; Joachim Morschhäuser
Journal:  Antimicrob Agents Chemother       Date:  2007-10-22       Impact factor: 5.191

8.  Erythematous oral candidiasis in patients with controlled type II diabetes mellitus and complete dentures.

Authors:  Arlindo C Motta-Silva; Natanael A Aleva; Jorge K Chavasco; Mônica C Armond; Julieta P França; Luciano José Pereira
Journal:  Mycopathologia       Date:  2009-09-17       Impact factor: 2.574

Review 9.  Candida albicans secreted aspartyl proteinases in virulence and pathogenesis.

Authors:  Julian R Naglik; Stephen J Challacombe; Bernhard Hube
Journal:  Microbiol Mol Biol Rev       Date:  2003-09       Impact factor: 11.056

10.  Absent reduction by HIV protease inhibitors of Candida albicans adhesion to endothelial cells.

Authors:  Barbara Falkensammer; Georg Pilz; Jasmin Bektić; Pankorn Imwidthaya; Karin Jöhrer; Cornelia Speth; Cornelia Lass-Flörl; Manfred P Dierich; Reinhard Würzner
Journal:  Mycoses       Date:  2007-05       Impact factor: 4.377
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