Literature DB >> 10428396

Synthesis and screening of a combinatorial library of naphthalene substituted chalcones: inhibitors of leukotriene B4.

A M Deshpande1, N P Argade, A A Natu, J Eckman.   

Abstract

A combinatorial mini library of naphthalene substituted chalcones has been prepared by solution phase chemistry. Screening of these mixtures for leukotriene B4 inhibitory activity using human whole blood assay (HWBL) afforded a lead compound, 1-(6-butoxy-2-naphthyl)-3-(4-nitrophenyl)-prop-2-en-1-one (K4A3) with an IC50 value of 18.5 microM.

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Year:  1999        PMID： 10428396     DOI： 10.1016/s0968-0896(99)00047-4

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  5 in total

1.  1-(2-Hy-droxy-4-meth-oxy-phen-yl)-3-(4-methyl-phen-yl)prop-2-en-1-one.

Authors:  G B Thippeswamy; D Vijay Kumar; B S Jayashree; M A Sridhar; J Shashidhara Prasad
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-03-09

2.  Synthesis and Biological Evaluation of Chalcones having Heterosubstituent(s).

Authors:  S Kumar; K Nepali; S Sapra; O P Suri; K L Dhar; G S Sarma; A K Saxena
Journal:  Indian J Pharm Sci       Date:  2010-11       Impact factor: 0.975

Review 3.  A review on the development of urease inhibitors as antimicrobial agents against pathogenic bacteria.

Authors:  Yuri F Rego; Marcelo P Queiroz; Tiago O Brito; Priscila G Carvalho; Vagner T de Queiroz; Ângelo de Fátima; Fernando Macedo
Journal:  J Adv Res       Date:  2018-05-04       Impact factor: 10.479

4.  Synthesis of Novel Chalcone-Based Phenothiazine Derivatives as Antioxidant and Anticancer Agents.

Authors:  Nourah A Al Zahrani; Reda M El-Shishtawy; Mahmoud M Elaasser; Abdullah M Asiri
Journal:  Molecules       Date:  2020-10-06       Impact factor: 4.411

5.  Novel 3-(3, 5-difluoro-4-hydroxyphenyl)-1-(naphthalen-2-yl) prop-2-en-1-one as a potent inhibitor of MAP-kinase in HeLa cell lines and anti-angiogenic activity is mediated by HIF-1α in EAC animal model.

Authors:  Dileep Kumar M Guruswamy; Kyathegowdana Doddi Srivinavasa Balaji; Kattepura Krishnappa Dharmappa; Shankar Jayarama
Journal:  Oncotarget       Date:  2020-12-15
  5 in total

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