Literature DB >> 10428372

Increased stability of peptidesulfonamide peptidomimetics towards protease catalyzed degradation.

D B de Bont1, K M Sliedregt-Bol, L J Hofmeyer, R M Liskamp.   

Abstract

Replacement of amide bonds in peptides by sulfonamide moieties resulted in peptidosulfonamides with an increased stability towards protease catalyzed degradation. In addition to protection of the protease cleavage site, it was found that introduction of a sulfonamide also influenced the stability of adjacent amide bonds.

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Year:  1999        PMID： 10428372     DOI： 10.1016/s0968-0896(99)00021-8

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  3 in total

1.  Preparation and evaluation at the delta opioid receptor of a series of linear leu-enkephalin analogues obtained by systematic replacement of the amides.

Authors:  Kristina Rochon; Arnaud Proteau-Gagné; Philippe Bourassa; Jean-François Nadon; Jérome Côté; Véronique Bournival; Fernand Gobeil; Brigitte Guérin; Yves L Dory; Louis Gendron
Journal:  ACS Chem Neurosci       Date:  2013-05-20       Impact factor: 4.418

Review 2.  Peptide transformation leading to peptide-peptidosulfonamide hybrids and oligo peptidosulfonamides.

Authors:  Rob M J Liskamp; John A W Kruijtzer
Journal:  Mol Divers       Date:  2004       Impact factor: 2.943

Review 3.  Methods to Enhance the Metabolic Stability of Peptide-Based PET Radiopharmaceuticals.

Authors:  Brendan J Evans; Andrew T King; Andrew Katsifis; Lidia Matesic; Joanne F Jamie
Journal:  Molecules       Date:  2020-05-14       Impact factor: 4.411
  3 in total

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