| Literature DB >> 10426317 |
N P Hoe1, K Nakashima, S Lukomski, D Grigsby, M Liu, P Kordari, S J Dou, X Pan, J Vuopio-Varkila, S Salmelinna, A McGeer, D E Low, B Schwartz, A Schuchat, S Naidich, D De Lorenzo, Y X Fu, J M Musser.
Abstract
Serotype M1 group A Streptococcus strains cause epidemic waves of human infections long thought to be mono- or pauciclonal. The gene encoding an extracellular group A Streptococcus protein (streptococcal inhibitor of complement) that inhibits human complement was sequenced in 1,132 M1 strains recovered from population-based surveillance of infections in Canada, Finland and the United States. Epidemic waves are composed of strains expressing a remarkably heterogeneous array of variants of streptococcal inhibitor of complement that arise very rapidly by natural selection on mucosal surfaces. Thus, our results enhance the understanding of pathogen population dynamics in epidemic waves and infectious disease reemergence.Entities:
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Year: 1999 PMID： 10426317 DOI： 10.1038/11369
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440