Literature DB >> 10426282

Merck Frosst Award Lecture 1998. Molecular dissection of the human multidrug resistance P-glycoprotein.

T W Loo1, D M Clarke.   

Abstract

The human multidrug resistance P-glycoprotein is an ATP-dependent drug pump that extrudes a broad range of cytotoxic agents from the cell. Its physiological role may be to protect the body from endogenous and exogenous cytotoxic agents. The protein has clinical importance because it contributes to the phenomenon of multidrug resistance during chemotherapy. In this review, we discuss some of the results obtained by using molecular biology and protein chemistry techniques for studying this important and intriguing protein.

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Year:  1999        PMID： 10426282

Source DB:  PubMed          Journal:  Biochem Cell Biol        ISSN： 0829-8211            Impact factor:   3.626


  13 in total

1.  Drug Interactions with Antiretrovirals.

Authors: 
Journal:  Curr Infect Dis Rep       Date:  2000-06       Impact factor: 3.725

2.  Detection of P-glycoprotein-mediated multidrug resistance against anthelmintics in Haemonchus contortus using anti-human mdr1 monoclonal antibodies.

Authors:  D Kerboeuf; F Guégnard; Y Le Vern
Journal:  Parasitol Res       Date:  2003-07-29       Impact factor: 2.289

3.  Host cell P-glycoprotein is essential for cholesterol uptake and replication of Toxoplasma gondii.

Authors:  Iveta Bottova; Adrian B Hehl; Sasa Stefanić; Gemma Fabriàs; Josefina Casas; Elisabeth Schraner; Jean Pieters; Sabrina Sonda
Journal:  J Biol Chem       Date:  2009-04-22       Impact factor: 5.157

Review 4.  Changes in lipid and protein constituents of rafts and caveolae in multidrug resistant cancer cells and their functional consequences.

Authors:  Y Lavie; M Liscovitch
Journal:  Glycoconj J       Date:  2000 Mar-Apr       Impact factor: 2.916

5.  Identification of an immunodominant ABC transporter in methicillin-resistant Staphylococcus aureus infections.

Authors:  J P Burnie; R C Matthews; T Carter; E Beaulieu; M Donohoe; C Chapman; P Williamson; S J Hodgetts
Journal:  Infect Immun       Date:  2000-06       Impact factor: 3.441

6.  Evidence for modulation of P-glycoprotein-mediated efflux by methoxypolyethylene glycol-block-Polycaprolactone amphiphilic diblock copolymers.

Authors:  Jason Zastre; John Jackson; Helen Burt
Journal:  Pharm Res       Date:  2004-08       Impact factor: 4.200

7.  Resistance to thapsigargin-induced intracellular calcium mobilization in a multidrug resistant tumour cell line.

Authors:  Karen Wagner-Souza; Juliana Echevarria-Lima; Louise A P Rodrigues; Marcelo Reis; Vivian M Rumjanek
Journal:  Mol Cell Biochem       Date:  2003-10       Impact factor: 3.396

Review 8.  Identification and characterization of the binding sites of P-glycoprotein for multidrug resistance-related drugs and modulators.

Authors:  Ahmad R Safa
Journal:  Curr Med Chem Anticancer Agents       Date:  2004-01

9.  Carotenoids and their metabolites are naturally occurring activators of gene expression via the pregnane X receptor.

Authors:  Ralph Rühl; Ronny Sczech; Nico Landes; Paul Pfluger; Dirk Kluth; Florian J Schweigert
Journal:  Eur J Nutr       Date:  2004-12       Impact factor: 5.614

10.  PGP expression in Cooperia oncophora before and after ivermectin selection.

Authors:  Marlene Areskog; Annie Engström; Jonas Tallkvist; Georg von Samson-Himmelstjerna; Johan Höglund
Journal:  Parasitol Res       Date:  2013-06-15       Impact factor: 2.289
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