Literature DB >> 10425503

Total Synthesis of the Marine Natural Product 7-Deoxy-okadaic Acid: A Potent Inhibitor of Serine/Threonine-Specific Protein Phosphatases.

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Abstract

A small change to the structure of okadaic acid (1), the omission of the single hydroxy group at C7, facilitated substantially the first total synthesis of the derivative 7-deoxyokadaic acid (2). The conformation of 2 is in agreement with that of 1 and this minimal structural variation has been reported previously to have little effect on the inhibitory activity towards the serine/threonine-specific protein phosphatases PP-1 and PP-2A.

Entities:  

Year:  1999        PMID： 10425503

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  3 in total

1.  Structure-Activity Relationship Studies Using Natural and Synthetic Okadaic Acid/Dinophysistoxin Toxins.

Authors:  Michael J Twiner; Gregory J Doucette; Yucheng Pang; Chao Fang; Craig J Forsyth; Christopher O Miles
Journal:  Mar Drugs       Date:  2016-11-04       Impact factor: 5.118

2.  Identification of 24-O-β-d-Glycosides and 7-Deoxy-Analogues of Okadaic Acid and Dinophysistoxin-1 and -2 in Extracts from Dinophysis Blooms, Dinophysis and Prorocentrum Cultures, and Shellfish in Europe, North America and Australasia.

Authors:  Alistair L Wilkins; Thomas Rundberget; Morten Sandvik; Frode Rise; Brent K Knudsen; Jane Kilcoyne; Beatriz Reguera; Pilar Rial; Elliott J Wright; Sabrina D Giddings; Michael J Boundy; Cheryl Rafuse; Christopher O Miles
Journal:  Toxins (Basel)       Date:  2021-07-21       Impact factor: 4.546

3.  Contribution of natural inhibitors to the understanding of the PI3K/PDK1/PKB pathway in the insulin-mediated intracellular signaling cascade.

Authors:  Jae Youl Cho; Jongsun Park
Journal:  Int J Mol Sci       Date:  2008-11-12       Impact factor: 6.208
  3 in total

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