Literature DB >> 10425321

Poly(ethylenimine) and its role in gene delivery.

W T Godbey1, K K Wu, A G Mikos.   

Abstract

Since the first published examination of poly(ethylenimine) (PEI) as a gene delivery vehicle, there has been a flurry of research aimed at this polycation and its role in gene therapy. Here we will briefly review PEI chemistry and the characterization of PEI/DNA complexes used for gene delivery. Additionally, we will note various PEI transfection considerations and examine findings involving other polycationic gene delivery vehicles used with cellular targeting ligands. The current state of our knowledge regarding the mechanism of PEI/DNA transfection will also be discussed. Finally, we will survey toxicity issues related to PEI transfection.

Entities:  

Keywords:  Non-programmatic

Mesh：

Substances：

Year:  1999        PMID： 10425321     DOI： 10.1016/s0168-3659(99)00090-5

Source DB:  PubMed          Journal:  J Control Release        ISSN： 0168-3659            Impact factor:   9.776


  215 in total

1.  In vitro gene transfection in human glioma cells using a novel and less cytotoxic artificial lipoprotein delivery system.

Authors:  Guangliang Pan; Mohannad Shawer; Svein Oie; D Robert Lu
Journal:  Pharm Res       Date:  2003-05       Impact factor: 4.200

2.  Near-infrared fluorescent nanocapsules with reversible response to thermal/pH modulation for optical imaging.

Authors:  Yongping Chen; Xingde Li
Journal:  Biomacromolecules       Date:  2011-11-10       Impact factor: 6.988

Review 3.  Chlorotoxin-conjugated nanoparticles as potential glioma-targeted drugs.

Authors:  Yuejun Fu; Na An; Ke Li; Yali Zheng; Aihua Liang
Journal:  J Neurooncol       Date:  2011-11-23       Impact factor: 4.130

4.  Mutational and cysteine scanning analysis of the glucagon receptor N-terminal domain.

Authors:  Martine Prévost; Pascale Vertongen; Vincent Raussens; David Jonathan Roberts; Johnny Cnudde; Jason Perret; Magali Waelbroeck
Journal:  J Biol Chem       Date:  2010-07-20       Impact factor: 5.157

5.  Enzyme-synthesized poly(amine-co-esters) as nonviral vectors for gene delivery.

Authors:  Jie Liu; Zhaozhong Jiang; Jiangbing Zhou; Shengmin Zhang; W Mark Saltzman
Journal:  J Biomed Mater Res A       Date:  2010-12-09       Impact factor: 4.396

Review 6.  Gene Delivery in Neuro-Oncology.

Authors:  Karan Dixit; Priya Kumthekar
Journal:  Curr Oncol Rep       Date:  2017-09-02       Impact factor: 5.075

7.  Analysis of oseltamivir resistance substitutions in influenza virus glycoprotein neuraminidase using a lentivirus-based surrogate assay system.

Authors:  Jennifer Tisoncik-Go; Katie S Cordero; Lijun Rong
Journal:  Virol Sin       Date:  2013-02-06       Impact factor: 4.327

8.  Inhibition of ocular angiogenesis by siRNA targeting vascular endothelial growth factor pathway genes: therapeutic strategy for herpetic stromal keratitis.

Authors:  Bumseok Kim; Qingquan Tang; Partha S Biswas; Jun Xu; Raymond M Schiffelers; Frank Y Xie; Aslam M Ansari; Puthupparampil V Scaria; Martin C Woodle; Patrick Lu; Barry T Rouse
Journal:  Am J Pathol       Date:  2004-12       Impact factor: 4.307

Review 9.  Physical non-viral gene delivery methods for tissue engineering.

Authors:  Adam J Mellott; M Laird Forrest; Michael S Detamore
Journal:  Ann Biomed Eng       Date:  2012-10-26       Impact factor: 3.934

10.  Non-viral DNA delivery from porous hyaluronic acid hydrogels in mice.

Authors:  Talar Tokatlian; Cynthia Cam; Tatiana Segura
Journal:  Biomaterials       Date:  2014-01       Impact factor: 12.479
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