Two novel azadirachtin derivatives from azadirachta indica

Two novel compounds, the first 29-oxymethylene azadirachtin analogue, 29-oxymethylene-11- demethoxycarbonyl-11alpha-hydroxyazadirachtin (azadirachtin M) (1) and 22, 23-dihydro-23alpha-hydroxy-3-tigloyl-11-deoxyazadirachtinin (azadirachtin N) (2), together with known compound 11-epi-azadirachtin H were isolated from a methanolic extract of the seed kernels of Azadirachta indica. The structures of 1 and 2 were elucidated on the basis of spectral methods.