Literature DB >> 10425122

Microbial transformation of sampangine.

K Y Orabi1, E Li, A M Clark, C D Hufford.   

Abstract

Microbial transformation studies of the antifungal alkaloid sampangine (2) have revealed that it is metabolized by a number of microorganisms. Using a standard two-stage fermentation technique, Beauvaria bassiana (ATCC 7159), Doratomyces microsporus (ATCC 16225), and Filobasidiella neoformans (ATCC 10226) produced the 4'-O-methyl-beta-glucopyranose conjugate (3), while Absidia glauca (ATCC 22752), Cunninghamella elegans (ATCC 9245), Cunninghamella species (NRRL 5695), and Rhizopus arrhizus (ATCC 11145) produced the beta-glucopyranose conjugate (4). Metabolites 3 and 4 have been characterized on the basis of spectral data. Both 3 and 4 had significant in vitro activity against Cryptococcus neoformans but were inactive against Candida albicans. Metabolite 4 was inactive in vivo in a mouse model of cryptococcosis.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10425122     DOI： 10.1021/np980457a

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  5 in total

1.  Isolation and synthesis of antiproliferative eupolauridine alkaloids of Ambavia gerrardii from the Madagascar Dry Forest.

Authors:  Ende Pan; Shugeng Cao; Peggy J Brodie; Martin W Callmander; Richard Randrianaivo; Stephan Rakotonandrasana; Etienne Rakotobe; Vincent E Rasamison; Karen TenDyke; Yongchun Shen; Edward M Suh; David G I Kingston
Journal:  J Nat Prod       Date:  2011-04-19       Impact factor: 4.050

2.  Azaphenanthrene alkaloids with antitumoral activity from Anaxagorea dolichocarpa Sprague & Sandwith (Annonaceae).

Authors:  Ana Silvia Suassuna Carneiro Lúcio; Jackson Roberto Guedes da Silva Almeida; José Maria Barbosa-Filho; João Carlos Lima Rodrigues Pita; Marianna Vieira Sobral Castello Branco; Margareth de Fátima Formiga Melo Diniz; Maria de Fátima Agra; Emidio V L da-Cunha; Marcelo Sobral da Silva; Josean Fechine Tavares
Journal:  Molecules       Date:  2011-08-22       Impact factor: 4.411

3.  Controlled Production of Zearalenone-Glucopyranoside Standards with Cunninghamella Strains Using Sulphate-Depleted Media.

Authors:  Jeroen Peters; Edward Ash; Arjen Gerssen; Ruud Van Dam; Maurice C R Franssen; Michel W F Nielen
Journal:  Toxins (Basel)       Date:  2021-05-21       Impact factor: 4.546

4.  Valproic Acid Induces Antimicrobial Compound Production in Doratomyces microspores.

Authors:  Christoph Zutz; Markus Bacher; Alexandra Parich; Bernhard Kluger; Agnieszka Gacek-Matthews; Rainer Schuhmacher; Martin Wagner; Kathrin Rychli; Joseph Strauss
Journal:  Front Microbiol       Date:  2016-04-13       Impact factor: 5.640

Review 5.  Microbial Biotransformation to Obtain New Antifungals.

Authors:  Luiz F Bianchini; Maria F C Arruda; Sergio R Vieira; Patrícia M S Campelo; Ana M T Grégio; Edvaldo A R Rosa
Journal:  Front Microbiol       Date:  2015-12-24       Impact factor: 5.640
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.