| Literature DB >> 10424443 |
R A Merendino1, S Gangemi, A Misefari, A Arena, A B Capozza, S Chillemi, F P D'Ambrosio.
Abstract
Interleukin-10 (IL-10) and Interleukin 12 (IL-12) generation may be regulated by a complex monocyte and macrophage-derived cytokine network and an impairment of the immune system can be observed in neoplastic disease. In this study, we examined the production of these cytokines by phagocytic cells, obtained from breast cancer (BCa)-bearing patients. Our results suggest that an increased IL-10 formation may represent an important regulatory pathway of IL-12 production by BCa mononuclear cells. In this report, we show that mononuclear cells of patients affected by breast cancer have a defective IL-12 production capability while generating higher amounts of IL-10.Entities:
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Year: 1999 PMID： 10424443 DOI： 10.1016/s0165-2478(99)00067-x
Source DB: PubMed Journal: Immunol Lett ISSN： 0165-2478 Impact factor: 3.685