| Literature DB >> 10422872 |
A Bavec1, A Juréus, B Cigić, U Langel, M Zorko.
Abstract
Peptitergent PD1 shows complex effects on GTPase activity of rat brain cortical membranes: inhibition in the presence of lower concentrations of GTP and activation at a higher concentration, above 0.5 microM, of GTP. Its effect is dose dependent and is characterized by an EC50 of 1.8 +/- 0.2 microM and a Hill coefficient of 1.6 +/- 0.3, and it increases both Km and Vmax of the GTP hydrolysis. PD1 that was unable to solubilize G-proteins from the membranes probably acts on them by direct binding near the C-terminal alpha-helical region of the Galpha subunit, similarly to mastoparan.Entities:
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Year: 1999 PMID： 10422872 DOI： 10.1016/s0196-9781(98)00162-4
Source DB: PubMed Journal: Peptides ISSN： 0196-9781 Impact factor: 3.750