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Literature DB >> 10421565

Endocytosis: Is dynamin a 'blue collar' or 'white collar' worker?

Abstract

The GTPase dynamin clearly plays an important role in endocytosis, but precisely how has been controversial. Some recent results support the view that dynamin uses GTP hydrolysis physically to drive vesiculation; others support the view that dynamin acts as a classical G protein 'switch'. Perhaps both views are correct.

Entities: Chemical

Mesh：

Substances：

Year: 1999 PMID： 10421565 DOI： 10.1016/s0960-9822(99)80323-6

Source DB: PubMed Journal: Curr Biol ISSN： 0960-9822 Impact factor: 10.834

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Cited

7 in total

1. Crystal structure of a dynamin GTPase domain in both nucleotide-free and GDP-bound forms.

Authors: H H Niemann; M L Knetsch; A Scherer; D J Manstein; F J Kull
Journal: EMBO J Date: 2001-11-01 Impact factor: 11.598

Review 2. Mitochondrial morphology is dynamic and varied.

Authors: Daniel A Rube; Alexander M van der Bliek
Journal: Mol Cell Biochem Date: 2004 Jan-Feb Impact factor: 3.396

3. Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis.

Authors: Tom Kirchhausen; Eric Macia; Henry E Pelish
Journal: Methods Enzymol Date: 2008 Impact factor: 1.600

4. The GTPase effector domain sequence of the Dnm1p GTPase regulates self-assembly and controls a rate-limiting step in mitochondrial fission.

Authors: N H Fukushima; E Brisch; B R Keegan; W Bleazard; J M Shaw
Journal: Mol Biol Cell Date: 2001-09 Impact factor: 4.138

Endocytosis: Is dynamin a 'blue collar' or 'white collar' worker?

1. Crystal structure of a dynamin GTPase domain in both nucleotide-free and GDP-bound forms.

Review 2. Mitochondrial morphology is dynamic and varied.

3. Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis.

4. The GTPase effector domain sequence of the Dnm1p GTPase regulates self-assembly and controls a rate-limiting step in mitochondrial fission.

Review 5. Dissecting dynamin's role in clathrin-mediated endocytosis.

6. The role of dynamin and its binding partners in coated pit invagination and scission.

Review 7. Reciprocal regulation of signaling and endocytosis: Implications for the evolving cancer cell.