Literature DB >> 10421310

Haemochromatosis gene C282Y homozygotes in an elderly male population.

G Willis, J Z Wimperis, K C Smith, I W Fellows, B A Jennings.   

Abstract

We found that C282Y homozygosity was not under-represented in an elderly male population. This suggests that life-threatening, haemochromatosis-related disease may not occur in many C282Y homozygotes.

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Year:  1999        PMID： 10421310     DOI： 10.1016/S0140-6736(99)02195-9

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  15 in total

1.  Deaths attributed to haemochromatosis are rare in Britain.

Authors:  G Willis; I W Fellows; J Z Wimperis
Journal:  BMJ       Date:  2000-04-22

2.  Longevity and C282Y mutation for haemochromatosis: survival of C282Y homozygotes does not preclude screening for HFE mutations.

Authors:  Gavin Willis; Barbara A Jennings; Jennie Z Wimperis
Journal:  BMJ       Date:  2003-10-25

3.  Elevated serum transferrin saturation and mortality.

Authors:  Arch G Mainous; James M Gill; Peter J Carek
Journal:  Ann Fam Med       Date:  2004 Mar-Apr       Impact factor: 5.166

4.  [Genetics and quaternary prevention. The example of haemochromatosis].

Authors:  J Gérvas; M Pérez Fernández
Journal:  Aten Primaria       Date:  2003       Impact factor: 1.137

5.  Association of Hemochromatosis HFE p.C282Y Homozygosity With Hepatic Malignancy.

Authors:  Janice L Atkins; Luke C Pilling; Jane A H Masoli; Chia-Ling Kuo; Jeremy D Shearman; Paul C Adams; David Melzer
Journal:  JAMA       Date:  2020-11-24       Impact factor: 56.272

6.  HFE gene mutation (C282Y) and phenotypic expression among a hospitalised population in a high prevalence area of haemochromatosis.

Authors:  S Distante; J P Berg; K Lande; E Haug; H Bell
Journal:  Gut       Date:  2000-10       Impact factor: 23.059

Review 7.  Population screening for hemochromatosis: has the time finally come?

Authors:  J C Barton; R T Acton
Journal:  Curr Gastroenterol Rep       Date:  2000-02

8.  Incidence of liver disease in people with HFE mutations.

Authors:  G Willis; J Z Wimperis; R Lonsdale; I W Fellows; M A Watson; L M Skipper; B A Jennings
Journal:  Gut       Date:  2000-03       Impact factor: 23.059

9.  Screening for genetic haemochromatosis in blood samples with raised alanine aminotransferase.

Authors:  M Bhavnani; D Lloyd; A Bhattacharyya; J Marples; P Elton; M Worwood
Journal:  Gut       Date:  2000-05       Impact factor: 23.059

Review 10.  Clinical penetrance in hereditary hemochromatosis: estimates of the cumulative incidence of severe liver disease among HFE C282Y homozygotes.

Authors:  Scott D Grosse; Lyle C Gurrin; Nadine A Bertalli; Katrina J Allen
Journal:  Genet Med       Date:  2017-08-03       Impact factor: 8.822
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