Literature DB >> 10420987

The cytoplasmic domain of HIV-1 gp41 interacts with the carboxyl-terminal region of alpha-catenin.

E M Kim1, K H Lee, J W Kim.   

Abstract

To know the cellular protein interactions with the viral protein can give an insight into the molecular mechanisms of the virus life cycle. As the function of the cytoplasmic domain of human immunodeficiency virus type 1 (HIV-1) gp41 is not known clearly, we searched for a cellular protein that interacts with the cytoplasmic domain of the HIV-1 gp41 using the yeast two-hybrid assay system. Screening of HeLa cell cDNA library yielded alpha-catenin cDNA. The cytoplasmic domain of the HIV-1 gp41 and the simian immunodeficiency virus (SIV) gp41 were able to interact with the carboxyl-terminal region of alpha-catenin specifically. Mapping of the interaction sites revealed that the interaction between the domain containing the second helix structure from the carboxyl-terminus of HIV-1 gp41 and the carboxyl-terminal region of alpha-catenin was stronger than other domains of gp41.

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Year:  1999        PMID： 10420987

Source DB:  PubMed          Journal:  Mol Cells        ISSN： 1016-8478            Impact factor:   5.034


  14 in total

1.  A leucine zipper motif in the cytoplasmic domain of gp41 is required for HIV-1 replication and pathogenesis in vivo.

Authors:  S M Kao; E D Miller; L Su
Journal:  Virology       Date:  2001-10-25       Impact factor: 3.616

2.  Modulation of Env content in virions of simian immunodeficiency virus: correlation with cell surface expression and virion infectivity.

Authors:  Eloísa Yuste; Jacqueline D Reeves; Robert W Doms; Ronald C Desrosiers
Journal:  J Virol       Date:  2004-07       Impact factor: 5.103

3.  The cytoplasmic domain of the HIV-1 glycoprotein gp41 induces NF-κB activation through TGF-β-activated kinase 1.

Authors:  Thomas S Postler; Ronald C Desrosiers
Journal:  Cell Host Microbe       Date:  2012-02-16       Impact factor: 21.023

Review 4.  HIV-1 envelope glycoprotein biosynthesis, trafficking, and incorporation.

Authors:  Mary Ann Checkley; Benjamin G Luttge; Eric O Freed
Journal:  J Mol Biol       Date:  2011-07-22       Impact factor: 5.469

5.  Envelope glycoprotein cytoplasmic domains from diverse lentiviruses interact with the prenylated Rab acceptor.

Authors:  David T Evans; Karl C Tillman; Ronald C Desrosiers
Journal:  J Virol       Date:  2002-01       Impact factor: 5.103

6.  Regulation of human immunodeficiency virus type 1 envelope glycoprotein fusion by a membrane-interactive domain in the gp41 cytoplasmic tail.

Authors:  Stéphanie Wyss; Antony S Dimitrov; Frédéric Baribaud; Terri G Edwards; Robert Blumenthal; James A Hoxie
Journal:  J Virol       Date:  2005-10       Impact factor: 5.103

7.  Virion envelope content, infectivity, and neutralization sensitivity of simian immunodeficiency virus.

Authors:  Eloísa Yuste; Welkin Johnson; George N Pavlakis; Ronald C Desrosiers
Journal:  J Virol       Date:  2005-10       Impact factor: 5.103

8.  Rational site-directed mutations of the LLP-1 and LLP-2 lentivirus lytic peptide domains in the intracytoplasmic tail of human immunodeficiency virus type 1 gp41 indicate common functions in cell-cell fusion but distinct roles in virion envelope incorporation.

Authors:  Vandana Kalia; Surojit Sarkar; Phalguni Gupta; Ronald C Montelaro
Journal:  J Virol       Date:  2003-03       Impact factor: 5.103

9.  Identification of the cellular prohibitin 1/prohibitin 2 heterodimer as an interaction partner of the C-terminal cytoplasmic domain of the HIV-1 glycoprotein.

Authors:  Vanessa Emerson; Denise Holtkotte; Tanya Pfeiffer; I-Hsuan Wang; Martina Schnölzer; Tore Kempf; Valerie Bosch
Journal:  J Virol       Date:  2009-11-11       Impact factor: 5.103

Review 10.  The tale of the long tail: the cytoplasmic domain of HIV-1 gp41.

Authors:  Thomas S Postler; Ronald C Desrosiers
Journal:  J Virol       Date:  2012-10-17       Impact factor: 5.103
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