UNLABELLED: A new instrument for the measurement of choroidal blood flow in the fovea is presented. It is based on the laser Doppler method and a confocal optical system with an indirect detection of the Doppler shifted light. METHOD: The intensity of the laser beam (785 nm) at the cornea is 90 microW. Measurements were obtained from a normal population of 21 subjects under resting conditions without dilating the pupil. RESULTS: The reproducibility of the choroidal blood flow, based on 5 measurements of 10 s each in 5 randomly selected subjects, is 9%. The minimum detectable change for a statistical significance of p < or = 0.05, based on a population of 21 subjects and 10 s measurements, is 9%. CONCLUSION: This new compact instrument appears to be suitable for the investigation of the physiology and pharmacology of choroidal blood flow and the effect of age-related macular degeneration.
UNLABELLED: A new instrument for the measurement of choroidal blood flow in the fovea is presented. It is based on the laser Doppler method and a confocal optical system with an indirect detection of the Doppler shifted light. METHOD: The intensity of the laser beam (785 nm) at the cornea is 90 microW. Measurements were obtained from a normal population of 21 subjects under resting conditions without dilating the pupil. RESULTS: The reproducibility of the choroidal blood flow, based on 5 measurements of 10 s each in 5 randomly selected subjects, is 9%. The minimum detectable change for a statistical significance of p < or = 0.05, based on a population of 21 subjects and 10 s measurements, is 9%. CONCLUSION: This new compact instrument appears to be suitable for the investigation of the physiology and pharmacology of choroidal blood flow and the effect of age-related macular degeneration.
Authors: Reinhard Told; Stefan Palkovits; Helmuth Haslacher; Sophie Frantal; Doreen Schmidl; Agnes Boltz; Michael Lasta; Semira Kaya; René M Werkmeister; Gerhard Garhöfer; Leopold Schmetterer Journal: PLoS One Date: 2013-04-15 Impact factor: 3.240