Literature DB >> 10420081

Anticancer drug design based on plant-derived natural products.

K H Lee1.   

Abstract

This review article focuses on recent research in my laboratory on various classes of compounds that possess potent antitumor activity. These compounds were obtained by bioactivity- and mechanism of action-directed isolation and characterization coupled with rational drug design-based modification and analog synthesis. Structural modification, structure-activity relationship, and mechanism of action studies will be discussed.

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Year:  1999        PMID： 10420081     DOI： 10.1007/bf02253565

Source DB:  PubMed          Journal:  J Biomed Sci        ISSN： 1021-7770            Impact factor:   8.410


  25 in total

Review 1.  Targeting Glioblastoma with the Use of Phytocompounds and Nanoparticles.

Authors:  Francesca Pistollato; Susanne Bremer-Hoffmann; Giuseppe Basso; Sandra Sumalla Cano; Iñaki Elio; Manuel Masias Vergara; Francesca Giampieri; Maurizio Battino
Journal:  Target Oncol       Date:  2016-02       Impact factor: 4.493

2.  A polysaccharide from the alkaline extract of Glycyrrhiza inflata induces apoptosis of human oral cancer SCC-25 cells via mitochondrial pathway.

Authors:  Guang Zeng; Huan Shen; Guo Tang; Xingwei Cai; Lixia Bi; Bin Sun; Yongjin Yang; Wenxing Xun
Journal:  Tumour Biol       Date:  2015-04-03

3.  A polysaccharide from Glycyrrhiza inflata Licorice inhibits proliferation of human oral cancer cells by inducing apoptosis via mitochondrial pathway.

Authors:  Huan Shen; Guang Zeng; Bin Sun; Xingwei Cai; Lixia Bi; Guo Tang; Yongjin Yang
Journal:  Tumour Biol       Date:  2015-02-08

4.  Crystal structure determination of new antimitotic agent bis(p-fluorobenzyl)trisulfide.

Authors:  Haoyun An; Xiurong Hu; Jianming Gu; Linshen Chen; Weiming Xu; Xiaopeng Mo; Wanhong Xu; Xiaobo Wang; Xiao Xu
Journal:  AAPS PharmSciTech       Date:  2008-04-22       Impact factor: 3.246

5.  Antitumor activity of the Ailanthus altissima bark phytochemical ailanthone against breast cancer MCF-7 cells.

Authors:  Ruxing Wang; Yanjie Lu; Hong Li; Lixin Sun; Ning Yang; Mingzhen Zhao; Manli Zhang; Qingwen Shi
Journal:  Oncol Lett       Date:  2018-02-13       Impact factor: 2.967

6.  Chenopodium album prevents progression of cell growth and enhances cell toxicity in human breast cancer cell lines.

Authors:  Menka Khoobchandani; B K Ojeswi; Bhavna Sharma; Man Mohan Srivastava
Journal:  Oxid Med Cell Longev       Date:  2009 Jul-Aug       Impact factor: 6.543

7.  Substituents on etoposide that interact with human topoisomerase IIalpha in the binary enzyme-drug complex: contributions to etoposide binding and activity.

Authors:  Ryan P Bender; Michael J Jablonksy; Mohammad Shadid; Ian Romaine; Norma Dunlap; Clemens Anklin; David E Graves; Neil Osheroff
Journal:  Biochemistry       Date:  2008-03-21       Impact factor: 3.162

8.  Kuromoji (Lindera umbellata) essential oil-induced apoptosis and differentiation in human leukemia HL-60 cells.

Authors:  Hayato Maeda; Mao Yamazaki; Yohtaro Katagata
Journal:  Exp Ther Med       Date:  2011-09-27       Impact factor: 2.447

9.  In vitro cytotoxicity of Gymnema montanum in human leukaemia HL-60 cells; induction of apoptosis by mitochondrial membrane potential collapse.

Authors:  K M Ramkumar; C Manjula; B Elango; K Krishnamurthi; S Saravana Devi; P Rajaguru
Journal:  Cell Prolif       Date:  2013-06       Impact factor: 6.831

10.  Topoisomerase II - drug interaction domains: identification of substituents on etoposide that interact with the enzyme.

Authors:  Amy M Wilstermann; Ryan P Bender; Murrell Godfrey; Sungjo Choi; Clemens Anklin; David B Berkowitz; Neil Osheroff; David E Graves
Journal:  Biochemistry       Date:  2007-06-20       Impact factor: 3.162
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