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Literature DB >> 10418333

Antimalarial activity and cytotoxicity of (-)-roemrefidine isolated from the stem bark of Sparattanthelium amazonum.

V Muñoz, M Sauvain, P Mollinedo, J Callapa, I Rojas, A Gimenez, A Valentin, M Mallié.

Abstract

(-)-Roemrefidine, an aporphine alkaloid isolated from Sparattanthelium amazonum Martius (Hernandiaceae) a vine from Bolivia, has been found to be active against both resistant and sensitive strains of Plasmodium falciparum in vitro and against P. berghei in mice. The compound demonstrated no cytotoxic activity against three cell lines (KB, HEp-2 and HeLa).

Entities: Chemical Disease Species

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Year: 1999 PMID： 10418333 DOI： 10.1055/s-2006-960808

Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352

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Cited

7 in total

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4. Helichrysum gymnocephalum essential oil: chemical composition and cytotoxic, antimalarial and antioxidant activities, attribution of the activity origin by correlations.

Authors: Samia Afoulous; Hicham Ferhout; Emmanuel Guy Raoelison; Alexis Valentin; Béatrice Moukarzel; François Couderc; Jalloul Bouajila
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Antimalarial activity and cytotoxicity of (-)-roemrefidine isolated from the stem bark of Sparattanthelium amazonum.

1. Antiplasmodial activity of alkaloid extracts from Pavetta crassipes (K. Schum) and Acanthospermum hispidum (DC), two plants used in traditional medicine in Burkina Faso.

2. Biological activities of nitidine, a potential anti-malarial lead compound.

3. Antiplasmodial and leishmanicidal activities of 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives.

4. Helichrysum gymnocephalum essential oil: chemical composition and cytotoxic, antimalarial and antioxidant activities, attribution of the activity origin by correlations.

5. Polar compounds isolated from the leaves of Albertisia delagoensis (Menispermaceae).

6. Phytocytotoxicity of volatile constituents of essential oils from Sparattanthelium Mart. species (Hernandiaceae).

7. New amide derivatives of quinoxaline 1,4-di-N-oxide with leishmanicidal and antiplasmodial activities.