Literature DB >> 10418324

Flavonoids from Cleome droserifolia suppress NO production in activated macrophages in vitro.

S Fushiya1, Y Kishi, K Hattori, J Batkhuu, F Takano, A N Singab, T Okuyama.   

Abstract

The effect of an Egyptian medicinal plant, Cleome droserifolia (Forssk.) Del. on nitric oxide (NO) production in bacillus Calmette-Guérin-induced mouse peritoneal macrophages activated by lipopolysaccharide was investigated in vitro. The methanol extract of C. droserifolia reduced the NO production, and two flavonoids were isolated as the active components. The new one was determined to be 5,4'-dihydroxy-6,7,8,3',5'-pentamethoxyflavone (1) and the other was identified as 5,4'-dihydroxy-6,7,8,3'-tetramethoxyflavone (8-methoxycirsilineol; 2). Compound 1 concentration-dependently suppressed the NO production and was effective at a non-toxic concentration (12.5 micrograms/ml). The suppressive activity of 2 was weaker than that of 1.

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Year:  1999        PMID： 10418324     DOI： 10.1055/s-1999-14084

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  6 in total

1.  A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents.

Authors:  Kanokkarn Phromnoi; Simone Reuter; Bokyung Sung; Sahdeo Prasad; Ramaswamy Kannappan; Vivek R Yadav; Wisinee Chanmahasathien; Pornngarm Limtrakul; Bharat B Aggarwal
Journal:  Mol Pharmacol       Date:  2010-10-07       Impact factor: 4.436

Review 2.  Modulation of autoimmune diseases by nitric oxide.

Authors:  V K Singh; S Mehrotra; P Narayan; C M Pandey; S S Agarwal
Journal:  Immunol Res       Date:  2000       Impact factor: 2.829

Review 3.  Pharmacological and phytochemical appraisal of selected medicinal plants from jordan with claimed antidiabetic activities.

Authors:  Fatma U Afifi; Violet Kasabri
Journal:  Sci Pharm       Date:  2013-10-15

4.  Flavonol Glycosides: In Vitro Inhibition of DPPIV, Aldose Reductase and Combating Oxidative Stress are Potential Mechanisms for Mediating the Antidiabetic Activity of Cleome droserifolia.

Authors:  Amira Abdel Motaal; Heba H Salem; Dalia Almaghaslah; Abdulrhman Alsayari; Abdullatif Bin Muhsinah; Mohammad Y Alfaifi; Serag Eldin I Elbehairi; Ali A Shati; Hesham El-Askary
Journal:  Molecules       Date:  2020-12-11       Impact factor: 4.411

Review 5.  Diterpenoid Constituents of Psiadia punctulata and Evaluation of Their Antimicrobial Activity.

Authors:  Giuliana Donadio; Maria Giovanna Chini; Valentina Parisi; Francesca Mensitieri; Nicola Malafronte; Giuseppe Bifulco; Angela Bisio; Nunziatina De Tommasi; Ammar Bader
Journal:  J Nat Prod       Date:  2022-06-24       Impact factor: 4.803

6.  Terpenoids from Cleome droserifolia (Forssk.) Del.

Authors:  Hesham I El-Askary
Journal:  Molecules       Date:  2005-08-31       Impact factor: 4.411
  6 in total

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