Literature DB >> 10417386

An adhesin of the yeast pathogen Candida glabrata mediating adherence to human epithelial cells.

B P Cormack1, N Ghori, S Falkow.   

Abstract

Candida glabrata is an important fungal pathogen of humans that is responsible for about 15 percent of mucosal and systemic candidiasis. Candida glabrata adhered avidly to human epithelial cells in culture. By means of a genetic approach and a strategy allowing parallel screening of mutants, it was possible to clone a lectin from a Candida species. Deletion of this adhesin reduced adherence of C. glabrata to human epithelial cells by 95 percent. The adhesin, encoded by the EPA1 gene, is likely a glucan-cross-linked cell-wall protein and binds to host-cell carbohydrate, specifically recognizing asialo-lactosyl-containing carbohydrates.

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Year:  1999        PMID： 10417386     DOI： 10.1126/science.285.5427.578

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  128 in total

1.  A lipid transfer-like protein is necessary for lily pollen tube adhesion to an in vitro stylar matrix.

Authors:  S Y Park; G Y Jauh; J C Mollet; K J Eckard; E A Nothnagel; L L Walling; E M Lord
Journal:  Plant Cell       Date:  2000-01       Impact factor: 11.277

2.  Quantitative target display: a method to screen yeast mutants conferring quantitative phenotypes by 'mutant DNA fingerprints'.

Authors:  V M Sharma; R Chopra; I Ghosh; K Ganesan
Journal:  Nucleic Acids Res       Date:  2001-09-01       Impact factor: 16.971

3.  A lily stylar pectin is necessary for pollen tube adhesion to an in vitro stylar matrix.

Authors:  J C Mollet; S Y Park; E A Nothnagel; E M Lord
Journal:  Plant Cell       Date:  2000-09       Impact factor: 11.277

Review 4.  Molecular genetic and genomic approaches to the study of medically important fungi.

Authors:  P T Magee; Cheryl Gale; Judith Berman; Dana Davis
Journal:  Infect Immun       Date:  2003-05       Impact factor: 3.441

Review 5.  Strategies for the identification of virulence determinants in human pathogenic fungi.

Authors:  R Alonso-Monge; F Navarro-García; E Román; B Eisman; C Nombela; J Pla
Journal:  Curr Genet       Date:  2003-02-08       Impact factor: 3.886

6.  A Saccharomyces gene family involved in invasive growth, cell-cell adhesion, and mating.

Authors:  B Guo; C A Styles; Q Feng; G R Fink
Journal:  Proc Natl Acad Sci U S A       Date:  2000-10-24       Impact factor: 11.205

7.  Heterogeneous expression of the virulence-related adhesin Epa1 between individual cells and strains of the pathogen Candida glabrata.

Authors:  Samantha C Halliwell; Matthew C A Smith; Philippa Muston; Sara L Holland; Simon V Avery
Journal:  Eukaryot Cell       Date:  2011-12-02

8.  Cryptococcus neoformans virulence gene discovery through insertional mutagenesis.

Authors:  Alexander Idnurm; Jennifer L Reedy; Jesse C Nussbaum; Joseph Heitman
Journal:  Eukaryot Cell       Date:  2004-04

9.  Structural basis for promiscuity and specificity during Candida glabrata invasion of host epithelia.

Authors:  Manuel Maestre-Reyna; Rike Diderrich; Maik Stefan Veelders; Georg Eulenburg; Vitali Kalugin; Stefan Brückner; Petra Keller; Steffen Rupp; Hans-Ulrich Mösch; Lars-Oliver Essen
Journal:  Proc Natl Acad Sci U S A       Date:  2012-10-03       Impact factor: 11.205

10.  Endoplasmic reticulum localized PerA is required for cell wall integrity, azole drug resistance, and virulence in Aspergillus fumigatus.

Authors:  Dawoon Chung; Arsa Thammahong; Kelly M Shepardson; Sara J Blosser; Robert A Cramer
Journal:  Mol Microbiol       Date:  2014-05-09       Impact factor: 3.501
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