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Literature DB >> 10417186

Myeloperoxidase exerts microbicidal activity against Mycobacterium tuberculosis.

V Borelli¹, E Banfi, M G Perrotta, G Zabucchi.

Abstract

We investigated the antimycobacterial role of myeloperoxidase (MPO), one of the most abundant granule proteins in human neutrophils. Our data indicate that purified MPO, in the presence of hydrogen peroxide, exerts a consistent killing activity against Mycobacterium tuberculosis H37Rv and against a clinical isolate. The activity is time and dose dependent and requires the presence of chloride ions in the assay medium.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1999 PMID： 10417186 PMCID： PMC96719

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

26 in total

Review 1. Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing.

Authors: M B Hampton; A J Kettle; C C Winterbourn
Journal: Blood Date: 1998-11-01 Impact factor: 22.113

Review 2. Modern methods for assessing the drugs used in the chemotherapy of mycobacterial disease.

Authors: D A Mitchison
Journal: Soc Appl Bacteriol Symp Ser Date: 1996

3. Myeloperoxidase-mediated iodination in granulocytes.

Authors: I Olsson; T Olofsson; H Odeberg
Journal: Scand J Haematol Date: 1972

4. Killing of Mycobacterium microti by immunologically activated macrophages.

Authors: L Walker; D B Lowrie
Journal: Nature Date: 1981-09-03 Impact factor: 49.962

5. Uptake of recombinant myeloperoxidase, free or fused to Fc gamma, by macrophages enhances killing activity toward micro-organisms.

Authors: C Tournay; P J Courtoy; L Marodi; P Totté; J Werenne; A Jacquet; L Garcia-Quintana; A Bollen; N Moguilevsky
Journal: DNA Cell Biol Date: 1996-08 Impact factor: 3.311

6. New mechanism for glomerular injury. Myeloperoxidase-hydrogen peroxide-halide system.

Authors: R J Johnson; W G Couser; E Y Chi; S Adler; S J Klebanoff
Journal: J Clin Invest Date: 1987-05 Impact factor: 14.808

7. Chemokine secretion by human polymorphonuclear granulocytes after stimulation with Mycobacterium tuberculosis and lipoarabinomannan.

Authors: D D Riedel; S H Kaufmann
Journal: Infect Immun Date: 1997-11 Impact factor: 3.441

8. Toxic effect of the peroxidase-hydrogen peroxide-halide antimicrobial system on Mycobacterium leprae.

Authors: S J Klebanoff; C C Shepard
Journal: Infect Immun Date: 1984-05 Impact factor: 3.441

9. A simple procedure for the purification of eosinophil peroxidase from normal human blood.

Authors: R Menegazzi; G Zabucchi; P Patriarca
Journal: J Immunol Methods Date: 1986-07-24 Impact factor: 2.303

10. Levamisole stimulation of neutrophil chemotaxis and chemokinesis by protection of both the leucoattractant and the cellular chemotactic response from inactivation by the peroxidase/hydrogen peroxide/halide system in vitro.

Authors: R Anderson
Journal: Int Arch Allergy Appl Immunol Date: 1981

8 in total

1. Efferocytosis of Apoptotic Neutrophils Enhances Control of Mycobacterium tuberculosis in HIV-Coinfected Macrophages in a Myeloperoxidase-Dependent Manner.

Authors: Anna-Maria Andersson; Marie Larsson; Olle Stendahl; Robert Blomgran
Journal: J Innate Immun Date: 2019-06-27 Impact factor: 7.349

2. Mycobacterium tuberculosis expresses methionine sulphoxide reductases A and B that protect from killing by nitrite and hypochlorite.

Authors: Warren L Lee; Benjamin Gold; Crystal Darby; Nathan Brot; Xiuju Jiang; Luiz Pedro S de Carvalho; Daniel Wellner; Gregory St John; William R Jacobs; Carl Nathan
Journal: Mol Microbiol Date: 2009-02 Impact factor: 3.501

Myeloperoxidase exerts microbicidal activity against Mycobacterium tuberculosis.

Review 1. Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing.

Review 2. Modern methods for assessing the drugs used in the chemotherapy of mycobacterial disease.

3. Myeloperoxidase-mediated iodination in granulocytes.

4. Killing of Mycobacterium microti by immunologically activated macrophages.

5. Uptake of recombinant myeloperoxidase, free or fused to Fc gamma, by macrophages enhances killing activity toward micro-organisms.

6. New mechanism for glomerular injury. Myeloperoxidase-hydrogen peroxide-halide system.

7. Chemokine secretion by human polymorphonuclear granulocytes after stimulation with Mycobacterium tuberculosis and lipoarabinomannan.

8. Toxic effect of the peroxidase-hydrogen peroxide-halide antimicrobial system on Mycobacterium leprae.

9. A simple procedure for the purification of eosinophil peroxidase from normal human blood.

10. Levamisole stimulation of neutrophil chemotaxis and chemokinesis by protection of both the leucoattractant and the cellular chemotactic response from inactivation by the peroxidase/hydrogen peroxide/halide system in vitro.

1. Efferocytosis of Apoptotic Neutrophils Enhances Control of Mycobacterium tuberculosis in HIV-Coinfected Macrophages in a Myeloperoxidase-Dependent Manner.

2. Mycobacterium tuberculosis expresses methionine sulphoxide reductases A and B that protect from killing by nitrite and hypochlorite.

3. Study on myeloperoxidase role in antituberculous defense in the context of cytokine activation.

4. Human eosinophil peroxidase induces surface alteration, killing, and lysis of Mycobacterium tuberculosis.

5. Effect of reactive oxygen intermediaries on the viability and infectivity of Mycobacterium lepraemurium.

Review 6. Neutrophils in Tuberculosis: Cell Biology, Cellular Networking and Multitasking in Host Defense.

Review 7. Mechanisms of Fish Macrophage Antimicrobial Immunity.

Review 8. Antimicrobial Activity of Neutrophils Against Mycobacteria.