Literature DB >> 10416032

Mitochondrial coenzyme Q content and aging.

A Lass1, L Kwong, R S Sohal.   

Abstract

The main objective of this study was to determine the nature of the relationship between aging and mitochondrial coenzyme Q (CoQ) content. Mitochondria in the heart, skeletal muscle, kidney and brain of the mouse varied in both the amount of total CoQ (CoQ9 + CoQ10) content as well as in the ratio of the CoQ9 to CoQ10. CoQ content declined with age only in the skeletal muscle. Caloric restriction (CR) resulted in an increase in the amount of CoQ9 in skeletal muscle mitochondria. This effect was partially reversible upon termination of the caloric restriction regimen. Results suggest that a decrease in mitochondrial CoQ content is an integral aspect of aging in skeletal muscle.

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Year:  1999        PMID： 10416032     DOI： 10.1002/biof.5520090215

Source DB:  PubMed          Journal:  Biofactors        ISSN： 0951-6433            Impact factor:   6.113


  20 in total

1.  Calorie restriction modifies ubiquinone and COQ transcript levels in mouse tissues.

Authors:  Cristina Parrado-Fernández; Guillermo López-Lluch; Elisabet Rodríguez-Bies; Sara Santa-Cruz; Plácido Navas; Jon J Ramsey; José M Villalba
Journal:  Free Radic Biol Med       Date:  2011-03-27       Impact factor: 7.376

2.  Electronic connection between the quinone and cytochrome C redox pools and its role in regulation of mitochondrial electron transport and redox signaling.

Authors:  Marcin Sarewicz; Artur Osyczka
Journal:  Physiol Rev       Date:  2015-01       Impact factor: 37.312

3.  CYB5R3 overexpression preserves skeletal muscle mitochondria and autophagic signaling in aged transgenic mice.

Authors:  Sara López-Bellón; Sandra Rodríguez-López; José A González-Reyes; M Isabel Burón; Rafael de Cabo; José M Villalba
Journal:  Geroscience       Date:  2022-05-09       Impact factor: 7.713

4.  Evaluation of coenzyme Q as an antioxidant strategy for Alzheimer's disease.

Authors:  Teri L Wadsworth; James A Bishop; Anuradha S Pappu; Randall L Woltjer; Joseph F Quinn
Journal:  J Alzheimers Dis       Date:  2008-06       Impact factor: 4.472

5.  Muscle physiology changes induced by every other day feeding and endurance exercise in mice: effects on physical performance.

Authors:  Elizabeth Rodríguez-Bies; Sara Santa-Cruz Calvo; Angela Fontán-Lozano; José Peña Amaro; Francisco J Berral de la Rosa; Angel M Carrión; Plácido Navas; Guillermo López-Lluch
Journal:  PLoS One       Date:  2010-11-09       Impact factor: 3.240

Review 6.  Coenzyme Q, oxidative stress and aging.

Authors:  Rajindar S Sohal; Michael J Forster
Journal:  Mitochondrion       Date:  2007-03-30       Impact factor: 4.160

7.  Mitochondrial dysfunctions during aging: vitamin E deficiency or caloric restriction--two different ways of modulating stress.

Authors:  Tatiana Armeni; Giovanni Principato; José L Quiles; Carlo Pieri; Stefano Bompadre; Maurizio Battino
Journal:  J Bioenerg Biomembr       Date:  2003-04       Impact factor: 2.945

8.  Influence of diagnostic categories, age, and gender on antioxidative defense and lipid peroxidation in skeletal muscle of patients with neuromuscular diseases.

Authors:  Hans-Joerg Stuerenburg; Birgit Stangneth; Alfried Kohlschütter; Barbara Finckh
Journal:  J Am Aging Assoc       Date:  2003-01

9.  High-dose statin use does not impair aerobic capacity or skeletal muscle function in older adults.

Authors:  Tinna Traustadóttir; Anthoney A Stock; S Mitchell Harman
Journal:  Age (Dordr)       Date:  2008-08-21

10.  Coenzyme Q(10) supplementation reverses age-related impairments in spatial learning and lowers protein oxidation.

Authors:  Ritu A Shetty; Michael J Forster; Nathalie Sumien
Journal:  Age (Dordr)       Date:  2012-11-10
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