| Literature DB >> 10414602 |
Abstract
DBA/2J mice repeatedly exposed to ethanol (2 g/kg, i.p. every 48 h for 8 days) exhibit sensitization to the locomotor stimulant effects of ethanol. Pretreatment with the NMDA receptor antagonist dizocilpine (0.2-0.3 mg/kg, i.p.) completely prevents the development of sensitization. Thus, NMDA receptors appear to play an important role in behavioural sensitization to ethanol.Entities:
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Year: 1999 PMID: 10414602 DOI: 10.1093/alcalc/34.3.283
Source DB: PubMed Journal: Alcohol Alcohol ISSN: 0735-0414 Impact factor: 2.826