Literature DB >> 10414554

Multipoint linkage disequilibrium mapping with particular reference to the African-American population.

C Zheng1, R C Elston.   

Abstract

A new approach to scanning the genome is presented to detect linkage disequilibrium caused specifically by population admixture. In contrast to current linkage genome scanning methods to find causal genes for complex diseases, this new method should be powerful to find genes for multilocus traits, particularly those genes that lead to the highest population attributable risk. Such a scan using the African-American population is generally feasible for mapping common diseases. A conservative threshold is also provided for such association mapping.

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Year:  1999        PMID： 10414554     DOI： 10.1002/(SICI)1098-2272(1999)17:2<79::AID-GEPI1>3.0.CO;2-N

Source DB:  PubMed          Journal:  Genet Epidemiol        ISSN： 0741-0395            Impact factor:   2.135


  17 in total

1.  Multipoint linkage-disequilibrium-mapping approach based on the case-parent trio design.

Authors:  K Y Liang; F C Hsu; T H Beaty; K C Barnes
Journal:  Am J Hum Genet       Date:  2001-03-15       Impact factor: 11.025

2.  Significant admixture linkage disequilibrium across 30 cM around the FY locus in African Americans.

Authors:  J A Lautenberger; J C Stephens; S J O'Brien; M W Smith
Journal:  Am J Hum Genet       Date:  2000-03       Impact factor: 11.025

3.  A second-generation genomewide screen for asthma-susceptibility alleles in a founder population.

Authors:  C Ober; A Tsalenko; R Parry; N J Cox
Journal:  Am J Hum Genet       Date:  2000-10-05       Impact factor: 11.025

4.  Ethnic-difference markers for use in mapping by admixture linkage disequilibrium.

Authors:  Heather E Collins-Schramm; Carolyn M Phillips; Darwin J Operario; Jane S Lee; James L Weber; Robert L Hanson; William C Knowler; Richard Cooper; Hongzhe Li; Michael F Seldin
Journal:  Am J Hum Genet       Date:  2002-02-11       Impact factor: 11.025

5.  Markers for mapping by admixture linkage disequilibrium in African American and Hispanic populations.

Authors:  M W Smith; J A Lautenberger; H D Shin; J P Chretien; S Shrestha; D A Gilbert; S J O'Brien
Journal:  Am J Hum Genet       Date:  2001-11       Impact factor: 11.025

6.  A method for the assessment of disease associations with single-nucleotide polymorphism haplotypes and environmental variables in case-control studies.

Authors:  Lue Ping Zhao; Shuying Sue Li; Najma Khalid
Journal:  Am J Hum Genet       Date:  2003-04-16       Impact factor: 11.025

7.  Mexican American ancestry-informative markers: examination of population structure and marker characteristics in European Americans, Mexican Americans, Amerindians and Asians.

Authors:  Heather E Collins-Schramm; Bill Chima; Takanobu Morii; Kimberly Wah; Yolanda Figueroa; Lindsey A Criswell; Robert L Hanson; William C Knowler; Gabriel Silva; John W Belmont; Michael F Seldin
Journal:  Hum Genet       Date:  2003-11-20       Impact factor: 4.132

8.  Nonparametric disequilibrium mapping of functional sites using haplotypes of multiple tightly linked single-nucleotide polymorphism markers.

Authors:  Rong Cheng; Jennie Z Ma; Fred A Wright; Shili Lin; Xin Gao; Daolong Wang; Robert C Elston; Ming D Li
Journal:  Genetics       Date:  2003-07       Impact factor: 4.562

9.  Linkage analysis of a complex disease through use of admixed populations.

Authors:  Xiaofeng Zhu; Richard S Cooper; Robert C Elston
Journal:  Am J Hum Genet       Date:  2004-05-06       Impact factor: 11.025

10.  Putative ancestral origins of chromosomal segments in individual african americans: implications for admixture mapping.

Authors:  Michael F Seldin; Takanobu Morii; Heather E Collins-Schramm; Bill Chima; Rick Kittles; Lindsey A Criswell; Hongzhe Li
Journal:  Genome Res       Date:  2004-05-12       Impact factor: 9.043
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