AIMS: To estimate the incidence of corneal melting or necrotising keratitis in association with systemic disease in the Yorkshire Region and to determine the type and duration of the systemic association. METHODS: In a prospective study, vigorous attempts were made to identify all patients presenting with newly diagnosed corneal melting over a 3 year period. RESULTS: 27 patients were identified during the study period. Rheumatoid arthritis and Wegener's granulomatosis were the most common disease associations. Corneal melting was a late complication of rheumatoid arthritis, but usually occurred during early and overt systemic disease in patients with Wegener's granulomatosis. CONCLUSION: The annual incidence of corneal melting in the Yorkshire Region is 3.01/million/year (95% CI = 0.7-9.6).
AIMS: To estimate the incidence of corneal melting or necrotising keratitis in association with systemic disease in the Yorkshire Region and to determine the type and duration of the systemic association. METHODS: In a prospective study, vigorous attempts were made to identify all patients presenting with newly diagnosed corneal melting over a 3 year period. RESULTS: 27 patients were identified during the study period. Rheumatoid arthritis and Wegener's granulomatosis were the most common disease associations. Corneal melting was a late complication of rheumatoid arthritis, but usually occurred during early and overt systemic disease in patients with Wegener's granulomatosis. CONCLUSION: The annual incidence of corneal melting in the Yorkshire Region is 3.01/million/year (95% CI = 0.7-9.6).
Authors: Alexandra E Levitt; Katherine T McManus; Allison L McClellan; Janet L Davis; Raquel Goldhardt; Anat Galor Journal: Cornea Date: 2015-07 Impact factor: 2.651
Authors: Manjeet S Bhamra; Irfan Gondal; Abhimanyu Amarnani; Saul Betesh; Angelina Zhyvotovska; Wayne Scott; Milena Rodriguez-Alvarez; Douglas R Lazzaro; Isabel M McFarlane Journal: Int J Clin Res Trials Date: 2019-11-09