Literature DB >> 10412010

PhTx4, a new class of toxins from Phoneutria nigriventer spider venom, inhibits the glutamate uptake in rat brain synaptosomes.

R A Mafra1, S G Figueiredo, C R Diniz, M N Cordeiro, J D Cruz, M E De Lima.   

Abstract

We report the characterization of a new class of glutamate uptake inhibitors isolated from Phoneutria nigriventer venom. Glutamate transport activity was assayed in rat cerebrocortical synaptosomes by using [(3)H]-L-glutamate. PhTx4 inhibited glutamate uptake in a dose dependent manner. The IC(50) value obtained was 2.35+/-0.9 microg/ml which is in the observed range reported for glutamate uptake blockers. Tx4-7, one of PhTx4 toxins, showed the strongest inhibitory activity (50.3+/-0.69%, n=3). Copyright 1999 Elsevier Science B.V.

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Year:  1999        PMID： 10412010     DOI： 10.1016/s0006-8993(99)01472-9

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  10 in total

1.  Purification of a neuroprotective component of Parawixia bistriata spider venom that enhances glutamate uptake.

Authors:  Andréia Cristina Karklin Fontana; Renato Guizzo; Renê de Oliveira Beleboni; Antonio Renato Meirelles E Silva; Norberto Cysne Coimbra; Susan G Amara; Wagner Ferreira dos Santos; Joaquim Coutinho-Netto
Journal:  Br J Pharmacol       Date:  2003-08       Impact factor: 8.739

Review 2.  Phoneutria nigriventer venom: a cocktail of toxins that affect ion channels.

Authors:  Marcus V Gomez; Evanguedes Kalapothakis; Cristina Guatimosim; Marco A M Prado
Journal:  Cell Mol Neurobiol       Date:  2002-12       Impact factor: 5.046

3.  Intravitreal injection of peptides PnPa11 and PnPa13, derivatives of Phoneutria nigriventer spider venom, prevents retinal damage.

Authors:  Lays Fernanda Nunes Dourado; Flavia Rodrigues da Silva; Cibele Rodrigues Toledo; Carolina Nunes da Silva; Cleildo Pereira Santana; Bruna Lopes da Costa; Maria Elena de Lima; Armando da Silva Cunha
Journal:  J Venom Anim Toxins Incl Trop Dis       Date:  2020-09-23

4.  PnPP-19, a spider toxin peptide, induces peripheral antinociception through opioid and cannabinoid receptors and inhibition of neutral endopeptidase.

Authors:  A C N Freitas; D F Pacheco; M F M Machado; A K Carmona; I D G Duarte; M E de Lima
Journal:  Br J Pharmacol       Date:  2016-03-10       Impact factor: 8.739

5.  Tx2-6 toxin of the Phoneutria nigriventer spider potentiates rat erectile function.

Authors:  K P Nunes; A Costa-Gonçalves; L F Lanza; S F Cortes; M N Cordeiro; M Richardson; A M C Pimenta; R C Webb; R Leite; M E De Lima
Journal:  Toxicon       Date:  2008-02-26       Impact factor: 3.033

6.  Leftward shift in the voltage-dependence for Ca2+ currents activation induced by a new toxin from Phoneutria reidyi (Aranae, Ctenidae) venom.

Authors:  L B Vieira; A M C Pimenta; M Richardson; M P Bemquerer; H J Reis; J S Cruz; M V Gomez; M M Santoro; R Ferreira-de-Oliveira; S G Figueiredo; T P Snutch; M N Cordeiro
Journal:  Cell Mol Neurobiol       Date:  2006-12-07       Impact factor: 4.231

Review 7.  From toxins targeting ligand gated ion channels to therapeutic molecules.

Authors:  Adak Nasiripourdori; Valérie Taly; Thomas Grutter; Antoine Taly
Journal:  Toxins (Basel)       Date:  2011-03-21       Impact factor: 4.546

8.  Expression of VEGF and Flk-1 and Flt-1 receptors during blood-brain barrier (BBB) impairment following Phoneutria nigriventer spider venom exposure.

Authors:  Monique C P Mendonça; Edilene S Soares; Leila M Stávale; Catarina Rapôso; Andressa Coope; Evanguedes Kalapothakis; Maria Alice da Cruz-Höfling
Journal:  Toxins (Basel)       Date:  2013-12-18       Impact factor: 4.546

9.  Antinociceptive effect of PnTx4(5-5), a peptide from Phoneutria nigriventer spider venom, in rat models and the involvement of glutamatergic system.

Authors:  Camila Franco Batista Oliveira; Daniela Pereira Alves; Bruna Luiza Emerich; Suely Gomes de Figueiredo; Marta do Nascimento Cordeiro; Márcia Helena Borges; Michael Richardson; Adriano Monteiro de Castro Pimenta; Igor Dimitri Gama Duarte; Maria Elena de Lima
Journal:  J Venom Anim Toxins Incl Trop Dis       Date:  2019-08-12

10.  Vascular endothelial growth factor increases during blood-brain barrier-enhanced permeability caused by Phoneutria nigriventer spider venom.

Authors:  Monique C P Mendonça; Edilene S Soares; Leila M Stávale; Evanguedes Kalapothakis; Maria Alice Cruz-Höfling
Journal:  Biomed Res Int       Date:  2014-08-27       Impact factor: 3.411
  10 in total

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