Literature DB >> 10412

Conversion of cefamandole nafate to cefamandole sodium.

J M Indelicato, W L Wilham, B J Cerimele.   

Abstract

The rate of hydrolysis of the formyl moiety of cefamandole nafate was determined as a function of pH, temperature, and concentration of added sodium carbonate or tromethamine. The reaction rate was sensitive to hydroxide ion in the pH 5.5-8.0 range with half-life values of hours to minutes. Hydrolysis was rapid upon the addition of sodium carbonate or tromethamine. Chirality in the 7-D-mandelamido side chain was unaffected by hydrolysis.

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Year:  1976        PMID： 10412     DOI： 10.1002/jps.2600650811

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  5 in total

1.  Metabolic fate of [14C]cefamandole, a parenteral cephalosporin antibiotic, in rats and dogs.

Authors:  H R Sullivan; S L Due; D L Kau; J F Quay; W M Miller
Journal:  Antimicrob Agents Chemother       Date:  1977-07       Impact factor: 5.191

2.  Hydrolysis of cefamandole nafate in dialysis patients.

Authors:  R L Nielsen; R Wolen; F C Luft; T Ozawa
Journal:  Antimicrob Agents Chemother       Date:  1979-11       Impact factor: 5.191

3.  Comparison of cefamandole nafate to cefamandole by microbiological assay.

Authors:  C L Winely; J C Spears; J K Scott
Journal:  Antimicrob Agents Chemother       Date:  1979-09       Impact factor: 5.191

4.  Effect of cefamandole nafate on the toxicity of tobramycin.

Authors:  J S Wold; S A Turnipseed; W D Broddle; N V Owen
Journal:  Antimicrob Agents Chemother       Date:  1977-10       Impact factor: 5.191

5.  Delineation of the relative antibacterial activity of cefamandole and cefamandole nafate.

Authors:  J R Turner; D A Preston; J S Wold
Journal:  Antimicrob Agents Chemother       Date:  1977-07       Impact factor: 5.191
  5 in total

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