Update on immunoelectron microscopy in diagnostic dermatopathology and cutaneous biology.

Immunoelectron microscopy for diagnostic dermatopathology is hardly ever necessary. Immunoelectron microscopy, however, is very helpful in the work-up of interesting cases, for the study of genetic and autoimmune bullous diseases and for basic science studies, particularly in conjunction with molecular biology techniques. It is also very helpful for investigators requiring double labeling.