Literature DB >> 10407938

[Tablets in stool? A common problem!].

L V Schuerch1, J Nyfeler, G Holder, C Surber, W E Haefeli.   

Abstract

Patients and their physicians are often thrown into doubt by the excretion of apparently intact tablets in stools after oral drug administration. This occurs whenever patients receive certain pharmaceutical forms designed to prolong the rate of drug release. The active compound is continuously released during intestinal passage of these pharmaceutical forms and their insoluble coats are visibly excreted into stools wholly or in part. The assumption that the drug was not released from the tablet in these cases is therefore erroneous and no further action is required.

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Year:  1999        PMID: 10407938

Source DB:  PubMed          Journal:  Schweiz Med Wochenschr        ISSN: 0036-7672


  1 in total

1.  Presence of Tablet Remnants of Nevirapine Extended-Release in Stools and Its Impact on Virological Outcome in HIV-1-Infected Patients: A Prospective Cohort Study.

Authors:  Yi-Chieh Lee; Shu-Wen Lin; Mao-Yuan Chen; Sui-Yuan Chang; Ching-Hua Kuo; Wang-Huei Sheng; Szu-Min Hsieh; Hsin-Yun Sun; Hsi-Yen Chang; Mon-Ro Wu; Wen-Chun Liu; Pei-Ying Wu; Shang-Ping Yang; Jun-Yu Zhang; Yi-Ching Su; Yi-Zhen Luo; Chien-Ching Hung; Shan-Chwen Chang
Journal:  PLoS One       Date:  2015-10-14       Impact factor: 3.240

  1 in total

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