Literature DB >> 10406815

Evidence for linkage between essential hypertension and a putative locus on human chromosome 17.

J Baima1, M Nicolaou, F Schwartz, A L DeStefano, A Manolis, I Gavras, C Laffer, F Elijovich, L Farrer, C T Baldwin, H Gavras.   

Abstract

Several clinical and animal studies indicate that essential hypertension is inherited as a multifactorial trait with a significant genetic and environmental component. In the stroke-prone spontaneously hypertensive rat model, investigators have found evidence for linkage to blood pressure regulatory genes (quantitative trait loci) on rat chromosomes 2, 10, and X. In 1 human study of French and UK sib pairs, evidence for linkage has been reported to human chromosome 17q, the syntenic region of the rat chromosome 10 quantitative trait loci (QTL). Our study confirms this linkage (P=0.0005) and refines the location of the blood pressure QTL.

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Year:  1999        PMID： 10406815     DOI： 10.1161/01.hyp.34.1.4

Source DB:  PubMed          Journal:  Hypertension        ISSN： 0194-911X            Impact factor:   10.190


  13 in total

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10.  An investigation of genome-wide associations of hypertension with microsatellite markers in the family blood pressure program (FBPP).

Authors:  C Charles Gu; Steven C Hunt; Sharon Kardia; Stephen T Turner; Aravinda Chakravarti; Nicholas Schork; Richard Olshen; David Curb; Cashell Jaquish; Eric Boerwinkle; D C Rao
Journal:  Hum Genet       Date:  2007-03-20       Impact factor: 5.881
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